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6tm1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3== | |
| - | + | <StructureSection load='6tm1' size='340' side='right'caption='[[6tm1]], [[Resolution|resolution]] 3.71Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6tm1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TM1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TM1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tm1 OCA], [http://pdbe.org/6tm1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tm1 RCSB], [http://www.ebi.ac.uk/pdbsum/6tm1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tm1 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DOC10_HUMAN DOC10_HUMAN]] Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.[UniProtKB:Q8BZN6] [[http://www.uniprot.org/uniprot/RAC3_HUMAN RAC3_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.<ref>PMID:11956649</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Barford, D]] | [[Category: Barford, D]] | ||
| + | [[Category: Cronin, N]] | ||
| + | [[Category: Fan, D]] | ||
[[Category: Yang, J]] | [[Category: Yang, J]] | ||
| - | [[Category: | + | [[Category: Dock10 gef rac3 gtpase]] |
| - | [[Category: | + | [[Category: Signaling protein]] |
Revision as of 16:21, 22 January 2020
Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3
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