6uen
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of the respiratory syncytial virus RNA polymerase== | |
| - | + | <StructureSection load='6uen' size='340' side='right'caption='[[6uen]], [[Resolution|resolution]] 3.67Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6uen]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UEN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uen OCA], [http://pdbe.org/6uen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uen RCSB], [http://www.ebi.ac.uk/pdbsum/6uen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uen ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/G8EJ12_HRSV G8EJ12_HRSV]] Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The replicase mode is dependent on intracellular protein N concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals.[PIRNR:PIRNR000830] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cao, D]] | ||
[[Category: Gao, Y]] | [[Category: Gao, Y]] | ||
| - | [[Category: Cao, D]] | ||
[[Category: Liang, B]] | [[Category: Liang, B]] | ||
| + | [[Category: Viral protein]] | ||
| + | [[Category: Viral protein complex]] | ||
| + | [[Category: Viral protein-transferase complex]] | ||
Revision as of 16:22, 22 January 2020
Cryo-EM structure of the respiratory syncytial virus RNA polymerase
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