User:Ivan E. Wang/Sandbox 1
From Proteopedia
(Difference between revisions)
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| - | '''Retinal | + | = Introduction to the RPE65 = |
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| + | <StructureSection load='4rsc' size='500' side='right' caption='Figure 1: Emixustat and palmitate bound in the active site of RPE65' scene=''> | ||
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| + | Retinal pigment epithelium 65 (RPE65) also known as retinoid isomerohydrolase is a 65 kDa enzyme located within the human retinal pigment epithelium cells. PRE65 is responsible for the chemical conversion of ''all-trans''-retinyl ester to ''11-cis''-retinol in the visual cycle. | ||
| - | <StructureSection load='4rsc' size='500' side='right' caption='Figure 1: Emixustat bound in the active site of RPE65' scene=''> | ||
| - | Retinal pigment epithelium 65 (RPE65) also known as retinoid isomerohydrolase is a 65 kDa enzyme located within the human retinal pigment epithelium cells responsible for the chemical conversion of ''all-trans''-retinyl ester to ''11-cis''-retinol in the visual cycle. | ||
</StructureSection> | </StructureSection> | ||
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== Exogenous Ligand == | == Exogenous Ligand == | ||
| - | <StructureSection load='4ryy' size='340' side='right' caption='Figure 3:(R)-emixustat bound in the active site of RPE65' scene=''> | + | <StructureSection load='4ryy' size='340' side='right' caption='Figure 3:(R)-emixustat and palmitate bound in the active site of RPE65' scene=''> |
=== (''R'')-Emixustat (ACU-4429) === | === (''R'')-Emixustat (ACU-4429) === | ||
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</StructureSection> | </StructureSection> | ||
| - | <StructureSection load='4ryz' size='340' side='right' caption='Figure 4:(S)-emixustat bound in the active site of RPE65' scene=''> | + | <StructureSection load='4ryz' size='340' side='right' caption='Figure 4:(S)-emixustat and palmitate bound in the active site of RPE65' scene=''> |
=== (''S'')-Emixustat === | === (''S'')-Emixustat === | ||
(PLACEHOLDER) | (PLACEHOLDER) | ||
Revision as of 23:20, 28 January 2020
Contents |
Introduction to the RPE65
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Function
Structural Features of RPE65
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Enzymatic Catalyzed Reaction
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Protein-Ligand Interaction
Endogenous Ligand
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Exogenous Ligand
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R/S Enantiomers Differences
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Disease Implications
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Medical Relevance
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This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
References
- ↑ Shin Y, Moiseyev G, Petrukhin K, Cioffi CL, Muthuraman P, Takahashi Y, Ma JX. A novel RPE65 inhibitor CU239 suppresses visual cycle and prevents retinal degeneration. Biochim Biophys Acta Mol Basis Dis. 2018 Jul;1864(7):2420-2429. doi:, 10.1016/j.bbadis.2018.04.014. Epub 2018 Apr 21. PMID:29684583 doi:http://dx.doi.org/10.1016/j.bbadis.2018.04.014
