6jas

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'''Unreleased structure'''
 
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The entry 6jas is ON HOLD until Paper Publication
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==Human serum transferrin with iron citrate bound==
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<StructureSection load='6jas' size='340' side='right'caption='[[6jas]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors: Wang, M., Wang, H., Sun, H.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6jas]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6JAS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6JAS FirstGlance]. <br>
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Description: Human serum transferrin with iron citrate bound
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6jas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6jas OCA], [http://pdbe.org/6jas PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6jas RCSB], [http://www.ebi.ac.uk/pdbsum/6jas PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6jas ProSAT]</span></td></tr>
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[[Category: Wang, M]]
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Defects in TF are the cause of atransferrinemia (ATRAF) [MIM:[http://omim.org/entry/209300 209300]]. Atransferrinemia is rare autosomal recessive disorder characterized by iron overload and hypochromic anemia.<ref>PMID:11110675</ref> <ref>PMID:15466165</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRFE_HUMAN TRFE_HUMAN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Sun, H]]
[[Category: Sun, H]]
[[Category: Wang, H]]
[[Category: Wang, H]]
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[[Category: Wang, M]]
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[[Category: Iron]]
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[[Category: Metal transport]]
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[[Category: Transferrin]]

Revision as of 15:25, 29 January 2020

Human serum transferrin with iron citrate bound

PDB ID 6jas

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