6sdf

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'''Unreleased structure'''
 
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The entry 6sdf is ON HOLD until Paper Publication
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==N-terminal SH3 domain of Grb2 protein==
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<StructureSection load='6sdf' size='340' side='right'caption='[[6sdf]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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Authors: Bolgov, A.A., Korban, S.A., Luzik, D.A., Rogacheva, O.N., Zhemkov, V.A., Kim, M., Skrynnikov, N.R., Bezprozvanny, I.B.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6sdf]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SDF FirstGlance]. <br>
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Description: N-terminal SH3 domain of Grb2 protein
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sdf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sdf OCA], [http://pdbe.org/6sdf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sdf RCSB], [http://www.ebi.ac.uk/pdbsum/6sdf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sdf ProSAT]</span></td></tr>
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[[Category: Zhemkov, V.A]]
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</table>
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[[Category: Luzik, D.A]]
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== Function ==
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[[Category: Korban, S.A]]
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[[http://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
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[[Category: Rogacheva, O.N]]
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== References ==
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[[Category: Skrynnikov, N.R]]
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<references/>
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[[Category: Bezprozvanny, I.B]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Bezprozvanny, I B]]
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[[Category: Bolgov, A A]]
[[Category: Kim, M]]
[[Category: Kim, M]]
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[[Category: Bolgov, A.A]]
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[[Category: Korban, S A]]
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[[Category: Luzik, D A]]
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[[Category: Rogacheva, O N]]
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[[Category: Skrynnikov, N R]]
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[[Category: Zhemkov, V A]]
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[[Category: Grb2]]
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[[Category: Growth factor]]
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[[Category: Sh3-domain]]
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[[Category: Signaling protein]]

Revision as of 15:38, 29 January 2020

N-terminal SH3 domain of Grb2 protein

PDB ID 6sdf

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