6txs
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of the FERM domain and helical linker of human moesin bound to a CD44 peptide== |
| - | + | <StructureSection load='6txs' size='340' side='right'caption='[[6txs]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6txs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TXS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TXS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6txs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6txs OCA], [http://pdbe.org/6txs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6txs RCSB], [http://www.ebi.ac.uk/pdbsum/6txs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6txs ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/MOES_HUMAN MOES_HUMAN]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. May inhibit herpes simplex virus 1 infection at an early stage.<ref>PMID:21549406</ref> [[http://www.uniprot.org/uniprot/CD44_HUMAN CD44_HUMAN]] Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. |
| - | [[Category: | + | == References == |
| - | [[Category: Bradshaw, W | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Bradshaw, W J]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Edwards, A]] | ||
[[Category: Gileadi, O]] | [[Category: Gileadi, O]] | ||
| - | [[Category: | + | [[Category: Katis, V L]] |
| - | [[Category: | + | [[Category: Kelly, J J]] |
| + | [[Category: Alzheimer's disease]] | ||
| + | [[Category: Cd44]] | ||
| + | [[Category: Ferm domain]] | ||
| + | [[Category: Pip]] | ||
| + | [[Category: Protein binding]] | ||
Revision as of 15:43, 29 January 2020
The structure of the FERM domain and helical linker of human moesin bound to a CD44 peptide
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