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6qct
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qct OCA], [http://pdbe.org/6qct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qct RCSB], [http://www.ebi.ac.uk/pdbsum/6qct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qct ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qct OCA], [http://pdbe.org/6qct PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qct RCSB], [http://www.ebi.ac.uk/pdbsum/6qct PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qct ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/U3RL19_9INFB U3RL19_9INFB]] Plays an essential role in viral RNA transcription and replication by forming the heterotrimeric polymerase complex together with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using a unique mechanism called cap-snatching. It consists in the hijacking and cleavage of host capped pre-mRNAs. These short capped RNAs are then used as primers for viral mRNAs. The PB2 subunit is responsible for the binding of the 5' cap of cellular pre-mRNAs which are subsequently cleaved after 10-13 nucleotides by the PA subunit that carries the endonuclease activity.[HAMAP-Rule:MF_04063][SAAS:SAAS00956500] [[http://www.uniprot.org/uniprot/U3RSD4_9INFB U3RSD4_9INFB]] Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription. Recognizes and binds a wide range of cap structures of target pre-RNAs which are subsequently cleaved after 10-13 nucleotides by the viral protein PA. Plays a role in the initiation of the viral genome replication and modulates the activity of the ribonucleoprotein (RNP) complex.[HAMAP-Rule:MF_04062] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6qct" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6qct" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[RNA polymerase 3D structures|RNA polymerase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 16:17, 29 January 2020
Influenza B polymerase elongation complex
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