1afv

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[[Image:1afv.gif|left|200px]]
[[Image:1afv.gif|left|200px]]
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{{Structure
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|PDB= 1afv |SIZE=350|CAPTION= <scene name='initialview01'>1afv</scene>, resolution 3.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1afv", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CP1:Cyclophilin+Binding+Site'>CP1</scene> and <scene name='pdbsite=CP2:Cyclophilin+Binding+Site'>CP2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= GAG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 Human immunodeficiency virus 1])
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|DOMAIN=
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{{STRUCTURE_1afv| PDB=1afv | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1afv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1afv OCA], [http://www.ebi.ac.uk/pdbsum/1afv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1afv RCSB]</span>
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}}
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'''HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3'''
'''HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3'''
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[[Category: Summers, M F.]]
[[Category: Summers, M F.]]
[[Category: Tong, L.]]
[[Category: Tong, L.]]
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[[Category: capsid protein]]
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[[Category: Capsid protein]]
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[[Category: complex (viral capsid/immunoglobulin)]]
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[[Category: Hiv]]
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[[Category: hiv]]
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[[Category: P24]]
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[[Category: p24]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:12:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:39:17 2008''
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Revision as of 07:12, 2 May 2008

Image:1afv.gif

Template:STRUCTURE 1afv

HIV-1 CAPSID PROTEIN (P24) COMPLEX WITH FAB25.3


Overview

X-ray diffraction analysis of a human immunodeficiency virus (HIV-1) capsid (CA) protein shows that each monomer within the dimer consists of seven alpha-helices, five of which are arranged in a coiled coil-like structure. Sequence assignments were made for two of the helices, and tentative connectivity of the remainder of the protein was confirmed by the recent solution structure of a monomeric N-terminal fragment. The C-terminal third of the protein is mostly disordered in the crystal. The longest helices in the coiled coil-like structure are separated by a long, highly antigenic peptide that includes the binding site of an antibody fragment complexed with CA in the crystal. The site of binding of the Fab, the position of the antigenic loop and the site of cleavage between the matrix protein and CA establish the side of the dimer that would be on the exterior of the retroviral core.

About this Structure

1AFV is a Protein complex structure of sequences from Human immunodeficiency virus 1 and Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of dimeric HIV-1 capsid protein., Momany C, Kovari LC, Prongay AJ, Keller W, Gitti RK, Lee BM, Gorbalenya AE, Tong L, McClure J, Ehrlich LS, Summers MF, Carter C, Rossmann MG, Nat Struct Biol. 1996 Sep;3(9):763-70. PMID:8784350 Page seeded by OCA on Fri May 2 10:12:53 2008

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