6qpw

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'''Unreleased structure'''
 
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The entry 6qpw is ON HOLD until Paper Publication
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==Structural basis of cohesin ring opening==
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<StructureSection load='6qpw' size='340' side='right'caption='[[6qpw]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6qpw]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6QPW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6QPW FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6qpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6qpw OCA], [http://pdbe.org/6qpw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6qpw RCSB], [http://www.ebi.ac.uk/pdbsum/6qpw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6qpw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SCC1_YEAST SCC1_YEAST]] Cleavable component of the cohesin complex involved in chromosome cohesion during cell cycle. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by ESP1 and dissociates from chromatin, allowing sister chromatids to segregate.<ref>PMID:9335333</ref> <ref>PMID:9335334</ref> <ref>PMID:9491073</ref> <ref>PMID:10403247</ref> [[http://www.uniprot.org/uniprot/SMC3_YEAST SMC3_YEAST]] Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Li, Y]]
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[[Category: Muir, K W]]
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[[Category: Panne, D]]
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[[Category: Weis, F]]
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[[Category: Cell cycle]]
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[[Category: Chromatin]]
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[[Category: Cohesin]]
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[[Category: Genome segregation]]

Revision as of 08:06, 5 February 2020

Structural basis of cohesin ring opening

PDB ID 6qpw

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