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6rqr

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'''Unreleased structure'''
 
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The entry 6rqr is ON HOLD
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==Extended NHERF1 PDZ2 domain in complex with the PDZ-binding motif of CFTR==
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<StructureSection load='6rqr' size='340' side='right'caption='[[6rqr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6rqr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RQR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RQR FirstGlance]. <br>
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Description:
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Channel-conductance-controlling_ATPase Channel-conductance-controlling ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.6.1.6 5.6.1.6] </span></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rqr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rqr OCA], [http://pdbe.org/6rqr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rqr RCSB], [http://www.ebi.ac.uk/pdbsum/6rqr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rqr ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN]] Defects in SLC9A3R1 are the cause of hypophosphatemic nephrolithiasis/osteoporosis type 2 (NPHLOP2) [MIM:[http://omim.org/entry/612287 612287]]. Hypophosphatemia results from idiopathic renal phosphate loss. It contributes to the pathogenesis of hypophosphatemic urolithiasis (formation of urinary calculi) as well to that of hypophosphatemic osteoporosis (bone demineralization).<ref>PMID:18784102</ref> <ref>PMID:22506049</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/NHRF1_HUMAN NHRF1_HUMAN]] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli (By similarity). Involved in the regulation of phosphate reabsorption in the renal proximal tubules.<ref>PMID:9430655</ref> <ref>PMID:9096337</ref> <ref>PMID:10499588</ref> <ref>PMID:18784102</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Channel-conductance-controlling ATPase]]
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[[Category: Large Structures]]
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[[Category: Ford, R C]]
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[[Category: Martin, E R]]
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[[Category: Robinson, R C]]
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[[Category: Complex]]
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[[Category: Pdz]]
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[[Category: Pdz-binding motif]]
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[[Category: Protein binding]]

Revision as of 08:07, 5 February 2020

Extended NHERF1 PDZ2 domain in complex with the PDZ-binding motif of CFTR

PDB ID 6rqr

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