6sb3

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m (Protected "6sb3" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6sb3 is ON HOLD
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==CryoEM structure of murine perforin-2 ectodomain in a pre-pore form==
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<StructureSection load='6sb3' size='340' side='right'caption='[[6sb3]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6sb3]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SB3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SB3 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sb3 OCA], [http://pdbe.org/6sb3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sb3 RCSB], [http://www.ebi.ac.uk/pdbsum/6sb3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sb3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MPEG1_MOUSE MPEG1_MOUSE]] Plays a key role in the innate immune response following bacterial infection by polymerizing and inserting into the bacterial surface to form pores (PubMed:26402460). By breaching the surface of phagocytosed bacteria, allows antimicrobial effectors to enter the bacterial periplasmic space and degrade bacterial proteins such as superoxide dismutase sodC which contributes to bacterial virulence (PubMed:30249808). Shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (PubMed:23257510, PubMed:23753625, PubMed:26402460). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (PubMed:26831467). Required for the antibacterial activity of reactive oxygen species and nitric oxide (PubMed:26402460).<ref>PMID:23257510</ref> <ref>PMID:23753625</ref> <ref>PMID:26402460</ref> <ref>PMID:26831467</ref> <ref>PMID:30249808</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Gilbert, R J.C]]
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[[Category: Ni, T]]
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[[Category: Yu, X]]
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[[Category: Macpf]]
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[[Category: Pore-forming protein]]
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[[Category: Pre-pore]]
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[[Category: Toxin]]

Revision as of 08:09, 5 February 2020

CryoEM structure of murine perforin-2 ectodomain in a pre-pore form

PDB ID 6sb3

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