1ah1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1ah1.jpg|left|200px]]
[[Image:1ah1.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1ah1 |SIZE=350|CAPTION= <scene name='initialview01'>1ah1</scene>
+
The line below this paragraph, containing "STRUCTURE_1ah1", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=GL1:Glycosylation+Site'>GL1</scene> and <scene name='pdbsite=GL2:Glycosylation+Site'>GL2</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1ah1| PDB=1ah1 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ah1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ah1 OCA], [http://www.ebi.ac.uk/pdbsum/1ah1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ah1 RCSB]</span>
+
-
}}
+
'''CTLA-4, NMR, 20 STRUCTURES'''
'''CTLA-4, NMR, 20 STRUCTURES'''
Line 36: Line 33:
[[Category: Peach, R.]]
[[Category: Peach, R.]]
[[Category: Shaw, S Y.]]
[[Category: Shaw, S Y.]]
-
[[Category: immune response]]
+
[[Category: Immune response]]
-
[[Category: immunoglobulin]]
+
[[Category: Immunoglobulin]]
-
[[Category: immunoreceptor]]
+
[[Category: Immunoreceptor]]
-
[[Category: t cell receptor]]
+
[[Category: T cell receptor]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:15:28 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:40:04 2008''
+

Revision as of 07:15, 2 May 2008

Image:1ah1.jpg

Template:STRUCTURE 1ah1

CTLA-4, NMR, 20 STRUCTURES


Overview

The structure of human CTLA-4 reveals that residues Met 99, Tyr 100 and Tyr 104 of the M99YPPPY104 motif are adjacent to a patch of charged surface residues on the A'GFCC' face of the protein. Mutation of these residues, which are conserved in the CTLA-4/CD28 family, significantly reduces binding to CD80 and/or CD86, implicating this patch as a ligand binding site.

About this Structure

1AH1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Solution structure of human CTLA-4 and delineation of a CD80/CD86 binding site conserved in CD28., Metzler WJ, Bajorath J, Fenderson W, Shaw SY, Constantine KL, Naemura J, Leytze G, Peach RJ, Lavoie TB, Mueller L, Linsley PS, Nat Struct Biol. 1997 Jul;4(7):527-31. PMID:9228944 Page seeded by OCA on Fri May 2 10:15:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ah1"
Personal tools