Symporter
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
Dipeptide: <scene name='70/705726/Cv/5'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>. | Dipeptide: <scene name='70/705726/Cv/5'>H symporter binds the dipeptide</scene> between its N- and C-terminal bundles<ref>PMID:24916388</ref>. | ||
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| + | == 3D Structures of symporter == | ||
| + | [[Symporter 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
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**[[4ja4]], [[4qiq]] – EcSymp – ''Escherichia coli''<BR /> | **[[4ja4]], [[4qiq]] – EcSymp – ''Escherichia coli''<BR /> | ||
| - | **[[4ja3]] – EcSymp (mutant) <BR /> | + | **[[4ja3]], [[6n3i]] – EcSymp (mutant) <BR /> |
**[[4gby]] – EcSymp + xylose <BR /> | **[[4gby]] – EcSymp + xylose <BR /> | ||
**[[4gbz]], [[4gc0]] – EcSymp + glucose derivative<BR /> | **[[4gbz]], [[4gc0]] – EcSymp + glucose derivative<BR /> | ||
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*Oligopeptide/H+ symporter | *Oligopeptide/H+ symporter | ||
| - | **[[4lep]], [[4tph]] – SoSymp – ''Shewanella oneidensis''<BR /> | + | **[[4lep]], [[4tph]], [[6jkc]], [[6jkd]] – SoSymp – ''Shewanella oneidensis''<BR /> |
| - | **[[2xut]] – SoSymp (mutant) <BR /> | + | **[[6ji1]] – SoSymp – Cryo EM<BR />**[[2xut]] – SoSymp (mutant) <BR /> |
**[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR /> | **[[4tpg]], [[4tpj]] – SoSymp + tripeptide<BR /> | ||
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**[[3o7q]] – EcSymp <BR /> | **[[3o7q]] – EcSymp <BR /> | ||
**[[3o7p]] – EcSymp (mutant)<BR /> | **[[3o7p]] – EcSymp (mutant)<BR /> | ||
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| + | *Succinate-acetate/H+ symporter | ||
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| + | **[[5zug]] – EcSymp <BR /> | ||
*Lactose/H+ symporter | *Lactose/H+ symporter | ||
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**[[5x9r]], [[5xas]], [[5xat]] – KpSymp + citrate + Na – ''Klebsiella pneumoniae''<BR /> | **[[5x9r]], [[5xas]], [[5xat]] – KpSymp + citrate + Na – ''Klebsiella pneumoniae''<BR /> | ||
**[[4bpq]], [[5xar]] – KpSymp <BR /> | **[[4bpq]], [[5xar]] – KpSymp <BR /> | ||
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| + | *Sodium/alanine symporter | ||
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| + | **[[6csf]], [[6cse]] – Symp + antibody + alanine – ''Methanococcus maripaludis''<BR /> | ||
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| + | *Sodium/aspartate symporter | ||
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| + | **[[6bat]] – PhSymp + aspartate – ''Pyrococcus horikoshi''i<BR /> | ||
| + | **[[6bav]], [[6bau]] – PhSymp (mutant) + cysteine derivative<BR /> | ||
| + | **[[6bmi]] – PhSymp (mutant) + serine<BR /> | ||
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| + | *Sodium/glutamate symporter | ||
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| + | **[[4p6h]], [[4p3j]], [[4p1a]], [[3v8g]], [[3v8f]] – PhSymp <BR /> | ||
*Neurotransmitter/leucine symporter LeuT | *Neurotransmitter/leucine symporter LeuT | ||
Revision as of 10:37, 12 February 2020
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3D Structures of symporter
Updated on 12-February-2020
References
- ↑ Dohan O, De la Vieja A, Paroder V, Riedel C, Artani M, Reed M, Ginter CS, Carrasco N. The sodium/iodide Symporter (NIS): characterization, regulation, and medical significance. Endocr Rev. 2003 Feb;24(1):48-77. PMID:12588808 doi:http://dx.doi.org/10.1210/er.2001-0029
- ↑ Pohlenz J, Refetoff S. Mutations in the sodium/iodide symporter (NIS) gene as a cause for iodide transport defects and congenital hypothyroidism. Biochimie. 1999 May;81(5):469-76. PMID:10403177
- ↑ Lyons JA, Parker JL, Solcan N, Brinth A, Li D, Shah ST, Caffrey M, Newstead S. Structural basis for polyspecificity in the POT family of proton-coupled oligopeptide transporters. EMBO Rep. 2014 Jun 10. pii: e201338403. PMID:24916388 doi:http://dx.doi.org/10.15252/embr.201338403
