Syntaxin

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<scene name='80/801795/Cv/8'>Syntaxin 1a SNARE motif complex with VAMP2 SNARE motif and SNAP25 SNARE motif</scene> (PDB code [[3hd7]]). The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions<ref>PMID:19571812</ref>. <scene name='80/801795/Cv/0'>The interactions of the syntaxin 1a with AMP2 SNARE motif and SNAP25 SNARE motives</scene> (PDB code [[3ipd]]).
<scene name='80/801795/Cv/8'>Syntaxin 1a SNARE motif complex with VAMP2 SNARE motif and SNAP25 SNARE motif</scene> (PDB code [[3hd7]]). The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions<ref>PMID:19571812</ref>. <scene name='80/801795/Cv/0'>The interactions of the syntaxin 1a with AMP2 SNARE motif and SNAP25 SNARE motives</scene> (PDB code [[3ipd]]).
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==3D structures of syntaxin==
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[[Syntaxin 3D structures]]
</StructureSection>
</StructureSection>
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*Syntaxin 1
*Syntaxin 1
-
**[[2xhe]] – Stx1 + Unc18 – Monosiga brevicollis<br />
+
**[[2xhe]] – Stx1 + Unc18 – ''Monosiga brevicollis''<br />
-
*Syntaxin 1A
+
*Syntaxin 1A; domains: N-terminal 1-150; SNARE motif 190-264
**[[1ez3]] – rStx1a N-terminal – rat<br />
**[[1ez3]] – rStx1a N-terminal – rat<br />
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**[[1urq]] – rStx1a SNARE motif + SNAP25 + tomosyn<br />
**[[1urq]] – rStx1a SNARE motif + SNAP25 + tomosyn<br />
**[[1n7s]], [[3hd7]], [[1sfc]], [[3ipd]], [[3rk2]], [[3rl0]] – rStx1a SNARE motif + SNAP25 + VAMP2<br />
**[[1n7s]], [[3hd7]], [[1sfc]], [[3ipd]], [[3rk2]], [[3rl0]] – rStx1a SNARE motif + SNAP25 + VAMP2<br />
 +
**[[6mti]] – rStx1a SNARE motif + synaptotagmin C2A+C2B domains + VAMP2 + SNAP25 – Cryo EM<br />
 +
**[[6ip1]] – rStx1a + NAPA + VAMP2 + SNAP25 – Cryo EM<br />
**[[3rk3]], [[1kil]] – rStx1a SNARE motif + SNAP25 + complexin-1 + VAMP2<br />
**[[3rk3]], [[1kil]] – rStx1a SNARE motif + SNAP25 + complexin-1 + VAMP2<br />
**[[5ccg]], [[5cch]], [[5cci]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 <br />
**[[5ccg]], [[5cch]], [[5cci]] – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 <br />
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*Syntaxin 6
*Syntaxin 6
-
**[[1lvf]] – rStx6 N-terminal <br />
 
**[[4j2c]] – hStx6 + vacuolar protein sorting-associated protein peptide – human<br />
**[[4j2c]] – hStx6 + vacuolar protein sorting-associated protein peptide – human<br />
 +
**[[1lvf]] – rStx6 N-terminal <br />
*Syntaxin 7
*Syntaxin 7

Revision as of 11:28, 12 February 2020

Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code 3ipd)

Drag the structure with the mouse to rotate

3D structures of syntaxin

Updated on 12-February-2020

References

  1. Hussain S, Ringsevjen H, Egbenya DL, Skjervold TL, Davanger S. SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus. Front Mol Neurosci. 2016 Feb 5;9:10. doi: 10.3389/fnmol.2016.00010. eCollection, 2016. PMID:26903802 doi:http://dx.doi.org/10.3389/fnmol.2016.00010
  2. Liang B, Kiessling V, Tamm LK. Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate. Proc Natl Acad Sci U S A. 2013 Nov 11. PMID:24218570 doi:http://dx.doi.org/10.1073/pnas.1314699110
  3. Hussain S, Ringsevjen H, Egbenya DL, Skjervold TL, Davanger S. SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus. Front Mol Neurosci. 2016 Feb 5;9:10. doi: 10.3389/fnmol.2016.00010. eCollection, 2016. PMID:26903802 doi:http://dx.doi.org/10.3389/fnmol.2016.00010
  4. Stein A, Weber G, Wahl MC, Jahn R. Helical extension of the neuronal SNARE complex into the membrane. Nature. 2009 Jul 23;460(7254):525-8. Epub 2009 Jul 1. PMID:19571812 doi:10.1038/nature08156

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Michal Harel, Alexander Berchansky

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