5qu5
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Domain Swap in the first SH3 domain of human Nck1== | |
| - | + | <StructureSection load='5qu5' size='340' side='right'caption='[[5qu5]], [[Resolution|resolution]] 1.11Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5qu5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QU5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QU5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qu5 OCA], [http://pdbe.org/5qu5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qu5 RCSB], [http://www.ebi.ac.uk/pdbsum/5qu5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qu5 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NCK1_HUMAN NCK1_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref> <ref>PMID:17803907</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Benz, J]] | ||
| + | [[Category: Burger, D]] | ||
| + | [[Category: Rudolph, M G]] | ||
[[Category: Ruf, A]] | [[Category: Ruf, A]] | ||
[[Category: Schlatter, D]] | [[Category: Schlatter, D]] | ||
| - | [[Category: | + | [[Category: Adaptor]] |
| - | [[Category: | + | [[Category: Domain swap]] |
| - | [[Category: | + | [[Category: Peptide binding]] |
| + | [[Category: Sh3 domain]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 04:06, 13 February 2020
Domain Swap in the first SH3 domain of human Nck1
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