6h9g
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 1.== | |
| - | + | <StructureSection load='6h9g' size='340' side='right'caption='[[6h9g]], [[Resolution|resolution]] 11.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6h9g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_a_virus Influenza a virus] and [http://en.wikipedia.org/wiki/Influenza_a_virus_(strain_a/wilson-smith/1933_h1n1) Influenza a virus (strain a/wilson-smith/1933 h1n1)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H9G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h9g OCA], [http://pdbe.org/6h9g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h9g RCSB], [http://www.ebi.ac.uk/pdbsum/6h9g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h9g ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q1K9H2_I33A0 Q1K9H2_I33A0]] Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus (By similarity).[SAAS:SAAS002141_004_603280] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Influenza a virus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arranz, R]] | ||
| + | [[Category: Carlero, D]] | ||
| + | [[Category: Coloma, R]] | ||
| + | [[Category: Martin-Benito, J]] | ||
| + | [[Category: Munier, S]] | ||
| + | [[Category: Naffakh, N]] | ||
| + | [[Category: Ortin, J]] | ||
| + | [[Category: Rosa-Trevin, J M.de la]] | ||
| + | [[Category: Sorzano, C O.S]] | ||
| + | [[Category: Influenza a virus ribonucleoprotein rna binding protein]] | ||
| + | [[Category: Viral protein]] | ||
Revision as of 04:07, 13 February 2020
Influenza A nucleoprotein docked into 3D helical structure of the wild type ribonucleoprotein complex obtained using cryoEM. Conformation 1.
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