6ttk
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide== | |
| - | + | <StructureSection load='6ttk' size='340' side='right'caption='[[6ttk]], [[Resolution|resolution]] 2.38Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ttk]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TTK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TTK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ttk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ttk OCA], [http://pdbe.org/6ttk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ttk RCSB], [http://www.ebi.ac.uk/pdbsum/6ttk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ttk ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/KLH12_HUMAN KLH12_HUMAN]] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B) (PubMed:22358839, PubMed:27565346). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export (PubMed:27716508). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3 (PubMed:16547521). The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins (PubMed:18303015, PubMed:20100572, PubMed:27716508).<ref>PMID:16547521</ref> <ref>PMID:18303015</ref> <ref>PMID:20100572</ref> <ref>PMID:22358839</ref> <ref>PMID:27565346</ref> <ref>PMID:27716508</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Bullock, A N]] | ||
[[Category: Burgess-Brown, N]] | [[Category: Burgess-Brown, N]] | ||
[[Category: Chalk, R]] | [[Category: Chalk, R]] | ||
| - | [[Category: Williams, E]] | ||
| - | [[Category: Wang, D]] | ||
| - | [[Category: Von Delft, F]] | ||
| - | [[Category: Bullock, A.N]] | ||
| - | [[Category: Edwards, A.M]] | ||
[[Category: Chen, Z]] | [[Category: Chen, Z]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Edwards, A M]] | ||
| + | [[Category: Krojer, T]] | ||
| + | [[Category: Pike, A C.W]] | ||
[[Category: Strain-Damerell, C]] | [[Category: Strain-Damerell, C]] | ||
| - | [[Category: | + | [[Category: Wang, D]] |
| - | [[Category: | + | [[Category: Williams, E]] |
| + | [[Category: Complex]] | ||
| + | [[Category: Cullin3 e3 ligase]] | ||
| + | [[Category: Kelch]] | ||
| + | [[Category: Ligase]] | ||
| + | [[Category: Substrate peptide]] | ||
Revision as of 04:26, 13 February 2020
Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide
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