This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6u37
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of VX-phosphonylated hAChE in complex with oxime reactivator RS194B== | |
| - | + | <StructureSection load='6u37' size='340' side='right'caption='[[6u37]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6u37]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U37 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6U37 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=PQV:(2E)-N-[2-(azepan-1-yl)ethyl]-2-(hydroxyimino)acetamide'>PQV</scene>, <scene name='pdbligand=VX:O-ETHYLMETHYLPHOSPHONIC+ACID+ESTER+GROUP'>VX</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6u37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u37 OCA], [http://pdbe.org/6u37 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6u37 RCSB], [http://www.ebi.ac.uk/pdbsum/6u37 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6u37 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Acetylcholinesterase]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Gerlits, O]] | [[Category: Gerlits, O]] | ||
| + | [[Category: Kovalevsky, A]] | ||
[[Category: Radic, Z]] | [[Category: Radic, Z]] | ||
| - | [[Category: | + | [[Category: Hydrolase]] |
| + | [[Category: Oxime reactivator complex]] | ||
| + | [[Category: Vx-phosphonylated conjugate]] | ||
Revision as of 04:28, 13 February 2020
Structure of VX-phosphonylated hAChE in complex with oxime reactivator RS194B
| |||||||||||
