6umg
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor== | |
| - | + | <StructureSection load='6umg' size='340' side='right'caption='[[6umg]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6umg]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UMG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UMG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6umh|6umh]], [[6umi|6umi]], [[6umj|6umj]]</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6umg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6umg OCA], [http://pdbe.org/6umg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6umg RCSB], [http://www.ebi.ac.uk/pdbsum/6umg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6umg ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RAMP1_HUMAN RAMP1_HUMAN]] Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.<ref>PMID:9620797</ref> [[http://www.uniprot.org/uniprot/CALRL_HUMAN CALRL_HUMAN]] Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.<ref>PMID:22102369</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mohr, C]] | ||
| + | [[Category: Class b gpcr]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Fragment antigen binding]] | ||
| + | [[Category: Membrane protein-immune system complex]] | ||
Revision as of 04:29, 13 February 2020
Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor
| |||||||||||
