6xtj

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m (Protected "6xtj" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6xtj is ON HOLD
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==The high resolution structure of the FERM domain of human FERMT2==
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<StructureSection load='6xtj' size='340' side='right'caption='[[6xtj]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors: Bradshaw, W.J., Katis, V.L., Newman, J.A., von Delft, F., Arrowsmith, C.H., Edwards, A., Bountra, C., Gileadi, O.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6xtj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XTJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6XTJ FirstGlance]. <br>
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Description: The high resolution structure of the FERM domain of human FERMT2
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6xtj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xtj OCA], [http://pdbe.org/6xtj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xtj RCSB], [http://www.ebi.ac.uk/pdbsum/6xtj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xtj ProSAT]</span></td></tr>
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[[Category: Katis, V.L]]
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</table>
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[[Category: Arrowsmith, C.H]]
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== Function ==
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[[Category: Bradshaw, W.J]]
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[[http://www.uniprot.org/uniprot/FERM2_HUMAN FERM2_HUMAN]] Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling.<ref>PMID:12679033</ref> <ref>PMID:18458155</ref> <ref>PMID:21325030</ref> <ref>PMID:22699938</ref> <ref>PMID:22030399</ref> <ref>PMID:22078565</ref>
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[[Category: Von Delft, F]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Bradshaw, W J]]
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[[Category: Delft, F von]]
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[[Category: Edwards, A]]
[[Category: Gileadi, O]]
[[Category: Gileadi, O]]
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[[Category: Newman, J.A]]
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[[Category: Katis, V L]]
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[[Category: Edwards, A]]
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[[Category: Newman, J A]]
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[[Category: Bountra, C]]
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[[Category: Alzheimer's disease]]
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[[Category: Ferm domain]]
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[[Category: Integrin binding]]
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[[Category: Protein binding]]

Revision as of 04:31, 13 February 2020

The high resolution structure of the FERM domain of human FERMT2

PDB ID 6xtj

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OCA

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