Tetracycline repressor protein
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
TetR binds DNA with a helix-turn-helix motif. The <scene name='47/477771/Cv/4'>inhibitor TC binds in the active site to several TetR side chains and to an octahedraly-coordinated Mg+2 ion</scene> <ref>PMID:8153629</ref>. Water molecules are shown as red spheres. <scene name='47/477771/Cv/5'>Mg coordination site</scene>. | TetR binds DNA with a helix-turn-helix motif. The <scene name='47/477771/Cv/4'>inhibitor TC binds in the active site to several TetR side chains and to an octahedraly-coordinated Mg+2 ion</scene> <ref>PMID:8153629</ref>. Water molecules are shown as red spheres. <scene name='47/477771/Cv/5'>Mg coordination site</scene>. | ||
| + | == 3D Structures of tetracycline repressor protein== | ||
| + | [[Tetracycline repressor protein 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of tetracycline repressor protein== | == 3D Structures of tetracycline repressor protein== | ||
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**[[2vkv]] – EcTetR (mutant) + Mg + anhydro-TC<br /> | **[[2vkv]] – EcTetR (mutant) + Mg + anhydro-TC<br /> | ||
**[[4ac0]] – EcTetR + Mg + minocycline<br /> | **[[4ac0]] – EcTetR + Mg + minocycline<br /> | ||
| + | **[[6sy4]], [[6sy6]] – EcTetR B + Mg + RNA<br /> | ||
*Tetracycline repressor protein class D | *Tetracycline repressor protein class D | ||
**[[4v2f]] – EcTetR D - ''Escherichia coli'' <br /> | **[[4v2f]] – EcTetR D - ''Escherichia coli'' <br /> | ||
| - | **[[1bjz]], [[1a6i]], [[2ns7]], [[2xgc]], [[2xgd]], [[2xge]] - EcTetR (mutant) <br /> | + | **[[1bjz]], [[1a6i]], [[2ns7]], [[2xgc]], [[2xgd]], [[2xge]], [[6fts]] - EcTetR (mutant) <br /> |
**[[1qpi]] – EcTetR + DNA<br /> | **[[1qpi]] – EcTetR + DNA<br /> | ||
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**[[4b3a]] – EcTetR (mutant) + Mg + TC<br /> | **[[4b3a]] – EcTetR (mutant) + Mg + TC<br /> | ||
**[[2x9d]], [[4b1r]] – EcTetR (mutant) + chloro-TC<br /> | **[[2x9d]], [[4b1r]] – EcTetR (mutant) + chloro-TC<br /> | ||
| - | **[[1ork]], [[5fkk]], [[5fkl]], [[5fkm]], [[5fkn]], [[5fko]] | + | **[[1ork]], [[5fkk]], [[5fkl]], [[5fkm]], [[5fkn]], [[5fko]], [[6fpl]], [[6fpm]], [[6qjw]] - EcTetR (mutant) + Mg + TC derivative<br /> |
**[[2fj1]] – EcTetR (mutant) + Ni + chloro-TC<br /> | **[[2fj1]] – EcTetR (mutant) + Ni + chloro-TC<br /> | ||
| - | **[[2o7o]], [[2xrl]] – EcTetR (mutant) + Mg + doxy-TC<br /> | + | **[[2o7o]], [[2xrl]], [[6rbl]], [[6rcr]], [[6rgx]] – EcTetR (mutant) + Mg + doxy-TC<br /> |
**[[2ns8]] – EcTetR (mutant) + Mg + TC peptide mimic<br /> | **[[2ns8]] – EcTetR (mutant) + Mg + TC peptide mimic<br /> | ||
**[[2vke]] – EcTetR + Co + TC<br /> | **[[2vke]] – EcTetR + Co + TC<br /> | ||
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**[[2xb5]] – EcTetR + Mg + iodo-TC<br /> | **[[2xb5]] – EcTetR + Mg + iodo-TC<br /> | ||
**[[2xpv]] – EcTetR + Mg + minocycline<br /> | **[[2xpv]] – EcTetR + Mg + minocycline<br /> | ||
| + | **[[6qjx]], [[6rbm]] – EcTetR D (mutant) + Mg + minocycline<br /> | ||
**[[4abz]] – EcTetR + Mg + tigecycline<br /> | **[[4abz]] – EcTetR + Mg + tigecycline<br /> | ||
**[[2xpw]] – EcTetR + Mg + oxy-TC<br /> | **[[2xpw]] – EcTetR + Mg + oxy-TC<br /> | ||
Revision as of 10:44, 16 February 2020
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3D Structures of tetracycline repressor protein
Updated on 16-February-2020
References
- ↑ Bertram R, Hillen W. The application of Tet repressor in prokaryotic gene regulation and expression. Microb Biotechnol. 2008 Jan;1(1):2-16. doi: 10.1111/j.1751-7915.2007.00001.x. PMID:21261817 doi:http://dx.doi.org/10.1111/j.1751-7915.2007.00001.x
- ↑ Hinrichs W, Kisker C, Duvel M, Muller A, Tovar K, Hillen W, Saenger W. Structure of the Tet repressor-tetracycline complex and regulation of antibiotic resistance. Science. 1994 Apr 15;264(5157):418-20. PMID:8153629
