6mf6
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of budding yeast Cdc5 polo-box domain in complex with the Dbf4 polo-interacting region.== | |
| - | + | <StructureSection load='6mf6' size='340' side='right'caption='[[6mf6]], [[Resolution|resolution]] 3.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6mf6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6MF6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6MF6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polo_kinase Polo kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.21 2.7.11.21] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6mf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6mf6 OCA], [http://pdbe.org/6mf6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6mf6 RCSB], [http://www.ebi.ac.uk/pdbsum/6mf6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6mf6 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CDC5_YEAST CDC5_YEAST]] Protein kinase required for the cell cycle where it is involved in mitotic exit. A component of the fear (CDC14 early anaphase release) network which promotes CDC14 release from the nucleolus during early anaphase. Phosphorylates SCC1/MCD1 and NET1.<ref>PMID:11371343</ref> <ref>PMID:11832211</ref> <ref>PMID:12056824</ref> [[http://www.uniprot.org/uniprot/DBF4_YEAST DBF4_YEAST]] Regulatory subunit of the CDC7-DBF4 kinase, also called DBF4-dependent kinase (DDK), which is involved in cell cycle regulation of premitotic and premeiotic chromosome replication and in chromosome segregation. DDK plays an essential role in initiating DNA replication at replication origins by phosphorylating the MCM2 and MCM4 subunits of the MCM2-7 helicase complex. DBF4 recruits the catalytic subunit CDC7 to MCM2 and to origins of replication. DDK has also postreplicative functions in meiosis. DDK phosphorylates the meiosis-specific double-strand break protein MER2 for initiation of meiotic recombination. Interacts with CDC5 during meiosis to promote double-strand breaks and monopolar spindle orientation. Inhibits CDC5 activity during mitosis through direct binding to its PBD.<ref>PMID:8066465</ref> <ref>PMID:12441400</ref> <ref>PMID:16319063</ref> <ref>PMID:17018296</ref> <ref>PMID:19013276</ref> <ref>PMID:18245450</ref> <ref>PMID:19692334</ref> <ref>PMID:19478884</ref> <ref>PMID:20436286</ref> <ref>PMID:21036905</ref> <ref>PMID:20170732</ref> <ref>PMID:20054399</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Polo kinase]] | ||
| + | [[Category: Almawi, A W]] | ||
[[Category: Guarne, A]] | [[Category: Guarne, A]] | ||
| - | [[Category: | + | [[Category: Cell cycle]] |
| + | [[Category: Dbf4]] | ||
| + | [[Category: Mitosis]] | ||
| + | [[Category: Polo-like kinase]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 06:23, 19 February 2020
Crystal structure of budding yeast Cdc5 polo-box domain in complex with the Dbf4 polo-interacting region.
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