1aj5

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[[Image:1aj5.gif|left|200px]]
[[Image:1aj5.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1aj5 |SIZE=350|CAPTION= <scene name='initialview01'>1aj5</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1aj5", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Hydrolase Hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.52 and 3.4.22.53 3.4.22.52 and 3.4.22.53] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CAPN4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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|DOMAIN=
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{{STRUCTURE_1aj5| PDB=1aj5 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aj5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aj5 OCA], [http://www.ebi.ac.uk/pdbsum/1aj5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aj5 RCSB]</span>
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'''CALPAIN DOMAIN VI APO'''
'''CALPAIN DOMAIN VI APO'''
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[[Category: Cygler, M.]]
[[Category: Cygler, M.]]
[[Category: Grochulski, P.]]
[[Category: Grochulski, P.]]
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[[Category: apo form]]
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[[Category: Apo form]]
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[[Category: calcium-binding protein]]
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[[Category: Calcium-binding protein]]
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[[Category: calcium-dependent protease]]
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[[Category: Calcium-dependent protease]]
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[[Category: small subunit]]
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[[Category: Small subunit]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:20:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:41:24 2008''
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Revision as of 07:20, 2 May 2008

Image:1aj5.gif

Template:STRUCTURE 1aj5

CALPAIN DOMAIN VI APO


Overview

The crystal structure of a Ca(2+)-binding domain (dVI) of rat m-calpain has been determined at 2.3 A resolution, both with and without bound Ca2+. The structures reveal a unique fold incorporating five EF-hand motifs per monomer, three of which bind calcium at physiological calcium concentrations, with one showing a novel EF-hand coordination pattern. This investigation gives us a first view of the calcium-induced conformational changes, and consequently an insight into the mechanism of calcium induced activation in calpain. The crystal structures reveal a dVI homodimer which provides a preliminary model for the subunit dimerization in calpain.

About this Structure

1AJ5 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes., Blanchard H, Grochulski P, Li Y, Arthur JS, Davies PL, Elce JS, Cygler M, Nat Struct Biol. 1997 Jul;4(7):532-8. PMID:9228945 Page seeded by OCA on Fri May 2 10:20:16 2008

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