6sws
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The DBB dimerization domain of B-cell adaptor for PI3K (BCAP) is required for down regulation of inflammatory signalling through the Toll-like receptor pathway== |
| - | + | <StructureSection load='6sws' size='340' side='right'caption='[[6sws]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6sws]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SWS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6SWS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6sws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sws OCA], [http://pdbe.org/6sws PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6sws RCSB], [http://www.ebi.ac.uk/pdbsum/6sws PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6sws ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| - | [[Category: Moncrieffe, M | + | == Function == |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/BCAP_HUMAN BCAP_HUMAN]] Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL.<ref>PMID:15893754</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Fisher, D]] | ||
| + | [[Category: Gay, N J]] | ||
| + | [[Category: Lauenstein, J U]] | ||
| + | [[Category: Moncrieffe, M C]] | ||
| + | [[Category: Scherm, M J]] | ||
[[Category: Udgata, A]] | [[Category: Udgata, A]] | ||
| - | [[Category: | + | [[Category: Dbb]] |
| - | [[Category: | + | [[Category: Tig/ipt]] |
| - | [[Category: | + | [[Category: Transcription]] |
| + | [[Category: Transcription factor]] | ||
Revision as of 06:35, 19 February 2020
The DBB dimerization domain of B-cell adaptor for PI3K (BCAP) is required for down regulation of inflammatory signalling through the Toll-like receptor pathway
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