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6xvx
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (high resolution)== | |
| + | <StructureSection load='6xvx' size='340' side='right'caption='[[6xvx]], [[Resolution|resolution]] 1.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6xvx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XVX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6XVX FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RH3:RHODIUM(III)+ION'>RH3</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.18 4.6.1.18] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6xvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xvx OCA], [http://pdbe.org/6xvx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xvx RCSB], [http://www.ebi.ac.uk/pdbsum/6xvx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xvx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The interactions between the cytotoxic paddlewheel dirhodium complex [Rh2(mu-O2CCH3)4] and the model protein bovine pancreatic ribonuclease (RNase A) were investigated by high-resolution mass spectrometry and X-ray crystallography. The results indicate that [Rh2(mu-O2CCH3)4] extensively reacts with RNase A. The metal compound binds the protein via coordination of the imidazole ring of a His side chain to one of its axial sites, while the dirhodium center and the acetato ligands remain unmodified. Data provide valuable information for the design of artificial dirhodium-containing metalloenzymes. | ||
| - | + | Protein interactions of dirhodium tetraacetate: a structural study.,Ferraro G, Pratesi A, Messori L, Merlino A Dalton Trans. 2020 Feb 5. doi: 10.1039/c9dt04819g. PMID:32022076<ref>PMID:32022076</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6xvx" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pancreatic ribonuclease]] | ||
[[Category: Ferraro, G]] | [[Category: Ferraro, G]] | ||
[[Category: Merlino, A]] | [[Category: Merlino, A]] | ||
| + | [[Category: Dirhodium]] | ||
| + | [[Category: Metalation]] | ||
| + | [[Category: Model protein]] | ||
| + | [[Category: Unknown function]] | ||
Revision as of 06:45, 19 February 2020
X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (high resolution)
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