1ajj

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[[Image:1ajj.gif|left|200px]]
[[Image:1ajj.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ajj |SIZE=350|CAPTION= <scene name='initialview01'>1ajj</scene>, resolution 1.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1ajj", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1ajj| PDB=1ajj | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ajj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ajj OCA], [http://www.ebi.ac.uk/pdbsum/1ajj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ajj RCSB]</span>
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}}
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'''LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING'''
'''LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING'''
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[[Category: Fass, D.]]
[[Category: Fass, D.]]
[[Category: Kim, P S.]]
[[Category: Kim, P S.]]
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[[Category: calcium]]
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[[Category: Calcium]]
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[[Category: cysteine-rich module]]
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[[Category: Cysteine-rich module]]
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[[Category: ldl receptor]]
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[[Category: Ldl receptor]]
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[[Category: receptor]]
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[[Category: Receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:21:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:41:34 2008''
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Revision as of 07:21, 2 May 2008

Image:1ajj.gif

Template:STRUCTURE 1ajj

LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING


Overview

The low-density lipoprotein receptor (LDLR) is responsible for the uptake of cholesterol-containing lipoprotein particles into cells. The amino-terminal region of LDLR, which consists of seven tandemly repeated, approximately 40-amino-acid, cysteine-rich modules (LDL-A modules), mediates binding to lipoproteins. LDL-A modules are biologically ubiquitous domains, found in over 100 proteins in the sequence database. The structure of ligand-binding repeat 5 (LR5) of the LDLR, determined to 1.7 A resolution by X-ray crystallography and presented here, contains a calcium ion coordinated by acidic residues that lie at the carboxy-terminal end of the domain and are conserved among LDL-A modules. Naturally occurring point mutations found in patients with the disease familial hypercholesterolaemia alter residues that directly coordinate Ca2+ or that serve as scaffolding residues of LR5.

About this Structure

1AJJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module., Fass D, Blacklow S, Kim PS, Berger JM, Nature. 1997 Aug 14;388(6643):691-3. PMID:9262405 Page seeded by OCA on Fri May 2 10:21:09 2008

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