Thiol:disulfide interchange protein

From Proteopedia

Revision as of 10:28, 20 February 2020

3D Structures of thiol:disulfide interchange protein

Updated on 20-February-2020

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• Thiol:disulfide interchange protein (DsbA) see Protein disulfide oxidoreductase

• Thiol:disulfide interchange protein (DsbB)

• • [[3e9j], 2zup] – EcDsbB (mutant) + DsbA (mutant) - Escherichal coli
    
  • 2leg] – EcDsbB (mutant) + DsbA (mutant) - NMR
    
  • 2hi7] – EcDsbB (mutant) + DsbA (mutant) + ubiquinone
    
  • 2zuq – EcDsbB (mutant) + antibody
    

• Thiol:disulfide interchange protein (DsbC)

• • 1eej, 1tjd – EcDsbC
    
  • 1g0t, 1jzo – EcDsbC (mutant)
    
  • 2iyj – EcDsbC N terminal
    
  • 1jzd – EcDsbC (mutant) + DsbD N terminal
    
  • 1t3b – DsbC – Haemophilus influenzae
    
  • 4fyb, 4fyc – HpDsbC – Helicobacter pylori
    
  • 4i5q – StDsbC – Salmonella typhimurium
    
  • 4ilf – StDsbC (mutant)
    
  • 4npb – DsbC – Yersinia pestis
    

• Thiol:disulfide interchange protein (DsbD)

• • 1l6p, 1jpe, 3pfu, 5nhi – EcDsbD N terminal
    
  • 1uc7, 2fwe, 2fwf 2fwg, 2fwh – EcDsbD C terminal
    
  • 4ip1, 4ip6 – EcDsbD C terminal (mutant)
    
  • 1vrs – EcDsbD N terminal (mutant) + C terminal (mutant)
    
  • 1z5y – EcDsbD N terminal (mutant) + EcDsbE soluble domain (mutant)
    
  • 2k0r, 6dnv, 6dps – NmDsbD N terminal – Neisseria meningitis
    
  • 6dnl, 6dnu – NmDsbD C terminal
    
  • 2k9f – NmDsbD N terminal + thoredoxin
    

• Thiol:disulfide interchange protein (DsbE)

• • 2b1k, 3k8n – EcDsbE
    
  • 2b1l, 2g0f – EcDsbE (mutant)
    
  • 3kh7, 3kh9 – DsbE soluble domain – Pseudomonas aeruginosa
    

• Thiol:disulfide interchange protein (DsbF)

• • 3ios – DsbF – Mycobacterium tuberculosis
    

• Thiol:disulfide interchange protein (DsbG)

• • 1v57, 1v58 – EcDsbG
    
  • 2h0g, 2h0h, 2h0i, 5g1k, 5g1l – EcDsbG (mutant)
    
  • 2iy2 – EcDsbG N terminal
    
  • 4ihu – MtDsbG
    
  • 3tdg – HpDsbG
    

• Thiol:disulfide interchange protein (DsbP)

• • 4ml1, 4ml6, 4mly – DsbP – Klebsiella pneumoniae
    

• Thiol:disulfide interchange protein (CycY)

• • 1kng – CycY – Bradyrhizobium japonicum
    

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References

1. ↑ Rietsch A, Bessette P, Georgiou G, Beckwith J. Reduction of the periplasmic disulfide bond isomerase, DsbC, occurs by passage of electrons from cytoplasmic thioredoxin. J Bacteriol. 1997 Nov;179(21):6602-8. PMID:9352906
2. ↑ Chung J, Chen T, Missiakas D. Transfer of electrons across the cytoplasmic membrane by DsbD, a membrane protein involved in thiol-disulphide exchange and protein folding in the bacterial periplasm. Mol Microbiol. 2000 Mar;35(5):1099-109. PMID:10712691
3. ↑ Goulding CW, Apostol MI, Gleiter S, Parseghian A, Bardwell J, Gennaro M, Eisenberg D. Gram-positive DsbE proteins function differently from Gram-negative DsbE homologs. A structure to function analysis of DsbE from Mycobacterium tuberculosis. J Biol Chem. 2004 Jan 30;279(5):3516-24. Epub 2003 Nov 3. PMID:14597624 doi:10.1074/jbc.M311833200
4. ↑ van Straaten M, Missiakas D, Raina S, Darby NJ. The functional properties of DsbG, a thiol-disulfide oxidoreductase from the periplasm of Escherichia coli. FEBS Lett. 1998 May 29;428(3):255-8. PMID:9654144
5. ↑ Bessette PH, Qiu J, Bardwell JC, Swartz JR, Georgiou G. Effect of sequences of the active-site dipeptides of DsbA and DsbC on in vivo folding of multidisulfide proteins in Escherichia coli. J Bacteriol. 2001 Feb;183(3):980-8. PMID:11208797 doi:http://dx.doi.org/10.1128/JB.183.3.980-988.2001
6. ↑ Bessette PH, Qiu J, Bardwell JC, Swartz JR, Georgiou G. Effect of sequences of the active-site dipeptides of DsbA and DsbC on in vivo folding of multidisulfide proteins in Escherichia coli. J Bacteriol. 2001 Feb;183(3):980-8. PMID:11208797 doi:http://dx.doi.org/10.1128/JB.183.3.980-988.2001