Thiol:disulfide interchange protein
From Proteopedia
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<StructureSection load='' size='340' side='right' caption='E. coli DsbC complex with MES (PDB code [[1eej]])' scene='70/705687/Cv/1'> | <StructureSection load='' size='340' side='right' caption='E. coli DsbC complex with MES (PDB code [[1eej]])' scene='70/705687/Cv/1'> | ||
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== Function == | == Function == | ||
'''Thiol:disulfide interchange protein''' is a prokaryotic disulfide bond isomerase. <br /> | '''Thiol:disulfide interchange protein''' is a prokaryotic disulfide bond isomerase. <br /> | ||
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</StructureSection> | </StructureSection> | ||
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| - | == 3D Structures of thiol:disulfide interchange protein == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Thiol:disulfide interchange protein (DsbA) see [[Protein disulfide oxidoreductase]] | ||
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| - | * Thiol:disulfide interchange protein (DsbB) | ||
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| - | **[[3e9j], [[2zup]]] – EcDsbB (mutant) + DsbA (mutant) - ''Escherichal coli'' <BR /> | ||
| - | **[[2leg]]] – EcDsbB (mutant) + DsbA (mutant) - NMR<BR /> | ||
| - | **[[2hi7]]] – EcDsbB (mutant) + DsbA (mutant) + ubiquinone <BR /> | ||
| - | **[[2zuq]] – EcDsbB (mutant) + antibody<BR /> | ||
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| - | *Thiol:disulfide interchange protein (DsbC) | ||
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| - | **[[1eej]], [[1tjd]] – EcDsbC <BR /> | ||
| - | **[[1g0t]], [[1jzo]] – EcDsbC (mutant) <BR /> | ||
| - | **[[2iyj]] – EcDsbC N terminal<BR /> | ||
| - | **[[1jzd]] – EcDsbC (mutant) + DsbD N terminal<BR /> | ||
| - | **[[1t3b]] – DsbC – ''Haemophilus influenzae'' <BR /> | ||
| - | **[[4fyb]], [[4fyc]] – HpDsbC – ''Helicobacter pylori'' <BR /> | ||
| - | **[[4i5q]] – StDsbC – ''Salmonella typhimurium''<BR /> | ||
| - | **[[4ilf]] – StDsbC (mutant) <BR /> | ||
| - | **[[4npb]] – DsbC –'' Yersinia pestis'' <BR /> | ||
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| - | *Thiol:disulfide interchange protein (DsbD) | ||
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| - | **[[1l6p]], [[1jpe]], [[3pfu]], [[5nhi]] – EcDsbD N terminal<BR /> | ||
| - | **[[1uc7]], [[2fwe]], [[2fwf]] [[2fwg]], [[2fwh]] – EcDsbD C terminal<BR /> | ||
| - | **[[4ip1]], [[4ip6]] – EcDsbD C terminal (mutant)<BR /> | ||
| - | **[[1vrs]] – EcDsbD N terminal (mutant) + C terminal (mutant)<BR /> | ||
| - | **[[1z5y]] – EcDsbD N terminal (mutant) + EcDsbE soluble domain (mutant)<BR /> | ||
| - | **[[2k0r]], [[6dnv]], [[6dps]] – NmDsbD N terminal – ''Neisseria meningitis''<BR /> | ||
| - | **[[6dnl]], [[6dnu]] – NmDsbD C terminal <BR /> | ||
| - | **[[2k9f]] – NmDsbD N terminal + thoredoxin<BR /> | ||
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| - | *Thiol:disulfide interchange protein (DsbE) | ||
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| - | **[[2b1k]], [[3k8n]] – EcDsbE <BR /> | ||
| - | **[[2b1l]], [[2g0f]] – EcDsbE (mutant) <BR /> | ||
| - | **[[3kh7]], [[3kh9]] – DsbE soluble domain – ''Pseudomonas aeruginosa''<BR /> | ||
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| - | *Thiol:disulfide interchange protein (DsbF) | ||
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| - | **[[3ios]] – DsbF – ''Mycobacterium tuberculosis'' <BR /> | ||
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| - | *Thiol:disulfide interchange protein (DsbG) | ||
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| - | **[[1v57]], [[1v58]] – EcDsbG <BR /> | ||
| - | **[[2h0g]], [[2h0h]], [[2h0i]], [[5g1k]], [[5g1l]] – EcDsbG (mutant) <BR /> | ||
| - | **[[2iy2]] – EcDsbG N terminal<BR /> | ||
| - | **[[4ihu]] – MtDsbG <BR /> | ||
| - | **[[3tdg]] – HpDsbG<BR /> | ||
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| - | *Thiol:disulfide interchange protein (DsbP) | ||
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| - | **[[4ml1]], [[4ml6]], [[4mly]] – DsbP – ''Klebsiella pneumoniae'' <BR /> | ||
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| - | *Thiol:disulfide interchange protein (CycY) | ||
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| - | **[[1kng]] – CycY – ''Bradyrhizobium japonicum'' <BR /> | ||
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| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Rietsch A, Bessette P, Georgiou G, Beckwith J. Reduction of the periplasmic disulfide bond isomerase, DsbC, occurs by passage of electrons from cytoplasmic thioredoxin. J Bacteriol. 1997 Nov;179(21):6602-8. PMID:9352906
- ↑ Chung J, Chen T, Missiakas D. Transfer of electrons across the cytoplasmic membrane by DsbD, a membrane protein involved in thiol-disulphide exchange and protein folding in the bacterial periplasm. Mol Microbiol. 2000 Mar;35(5):1099-109. PMID:10712691
- ↑ Goulding CW, Apostol MI, Gleiter S, Parseghian A, Bardwell J, Gennaro M, Eisenberg D. Gram-positive DsbE proteins function differently from Gram-negative DsbE homologs. A structure to function analysis of DsbE from Mycobacterium tuberculosis. J Biol Chem. 2004 Jan 30;279(5):3516-24. Epub 2003 Nov 3. PMID:14597624 doi:10.1074/jbc.M311833200
- ↑ van Straaten M, Missiakas D, Raina S, Darby NJ. The functional properties of DsbG, a thiol-disulfide oxidoreductase from the periplasm of Escherichia coli. FEBS Lett. 1998 May 29;428(3):255-8. PMID:9654144
- ↑ Bessette PH, Qiu J, Bardwell JC, Swartz JR, Georgiou G. Effect of sequences of the active-site dipeptides of DsbA and DsbC on in vivo folding of multidisulfide proteins in Escherichia coli. J Bacteriol. 2001 Feb;183(3):980-8. PMID:11208797 doi:http://dx.doi.org/10.1128/JB.183.3.980-988.2001
- ↑ Bessette PH, Qiu J, Bardwell JC, Swartz JR, Georgiou G. Effect of sequences of the active-site dipeptides of DsbA and DsbC on in vivo folding of multidisulfide proteins in Escherichia coli. J Bacteriol. 2001 Feb;183(3):980-8. PMID:11208797 doi:http://dx.doi.org/10.1128/JB.183.3.980-988.2001
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