Thioredoxin

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== Structural highlights ==
== Structural highlights ==
The <scene name='43/430885/Cv/4'>active site motif Cys-Gly-Pro-Cys</scene> is involved in the reduction of disulfide bonds in proteins<ref>PMID:8805557</ref>
The <scene name='43/430885/Cv/4'>active site motif Cys-Gly-Pro-Cys</scene> is involved in the reduction of disulfide bonds in proteins<ref>PMID:8805557</ref>
 +
 +
== 3D Structures of Thioredoxin ==
 +
[[Thioredoxin 3D structures]]
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</StructureSection>
</StructureSection>
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*Thioredoxin
*Thioredoxin
-
**[[3e3e]], [[2hsh]], [[1aiu]], [[1erv]], [[1erw]], [[3m9j]], [[3m9k]], [[4oo4]] – hTrx (mutant) – human<br />
+
**[[1auc]], [[1ert]], [[1eru]] - hTrx - human<br />
 +
**[[3e3e]], [[2hsh]], [[1aiu]], [[1erv]], [[1erw]], [[3m9j]], [[3m9k]], [[4oo4]] – hTrx (mutant) <br />
**[[2hxk]], [[2ifq]], [[2iiy]] – hTrx S-nitroso<br />
**[[2hxk]], [[2ifq]], [[2iiy]] – hTrx S-nitroso<br />
**[[4oo5]] - hTrx S-nitroso (mutant)<br />
**[[4oo5]] - hTrx S-nitroso (mutant)<br />
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**[[5dqy]] – hTrx oxidized<br />
**[[5dqy]] – hTrx oxidized<br />
**[[1trs]], [[1tru]], [[1trv]], [[1trw]], [[3trx]], [[4trx]] - hTrx - NMR<br />
**[[1trs]], [[1tru]], [[1trv]], [[1trw]], [[3trx]], [[4trx]] - hTrx - NMR<br />
 +
**[[1xw9]], [[1xwa]], [[1xwb]], [[1xwc]] – Trx – ''Drosophila melanogaster''<br />
 +
**[[1gl8]] – sTrx – spinach - NMR<br />
**[[3hxs]] – BfTrx fragment – ''Bacteroides fragilis''<br />
**[[3hxs]] – BfTrx fragment – ''Bacteroides fragilis''<br />
**[[3hyp]] - BfrxI fragment (mutant)<br />
**[[3hyp]] - BfrxI fragment (mutant)<br />
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**[[2f51]] – Trx – ''Trichomonas vaginalis''<br />
**[[2f51]] – Trx – ''Trichomonas vaginalis''<br />
**[[1t00]] – Trx – ''Streptomyces coelicolor''<br />
**[[1t00]] – Trx – ''Streptomyces coelicolor''<br />
-
**[[1xw9]], [[1xwa]], [[1xwb]], [[1xwc]] – Trx – ''Drosophila melanogaster''<br />
 
**[[1rqm]], [[1nsw]], [[1nw2]] – Trx (mutant) – ''Alicyclobacillus acidocaldarius'' – NMR<br />
**[[1rqm]], [[1nsw]], [[1nw2]] – Trx (mutant) – ''Alicyclobacillus acidocaldarius'' – NMR<br />
**[[1syr]] – PfTrx – ''Plasmodium falciparum''<br />
**[[1syr]] – PfTrx – ''Plasmodium falciparum''<br />
**[[2mmn]], [[2mmo]] - PfTrx - NMR<br />
**[[2mmn]], [[2mmo]] - PfTrx - NMR<br />
**[[1r26]] – Trx – ''Trypanosoma brucei brucei''<br />
**[[1r26]] – Trx – ''Trypanosoma brucei brucei''<br />
-
**[[1gl8]] – Trx – spinach - NMR<br />
 
**[[1fo5]] – Trx – ''Methanocaldococcus janaschii'' – NMR<br />
**[[1fo5]] – Trx – ''Methanocaldococcus janaschii'' – NMR<br />
**[[1quw]] – Trx – ''Bacillus acidocaldarius'' – NMR<br />
**[[1quw]] – Trx – ''Bacillus acidocaldarius'' – NMR<br />
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*Thioredoxin 1
*Thioredoxin 1
 +
**[[1oaz]] – Trx-1+immunoglobulin E – rat<br />
**[[3f3q]], [[2i9h]] – yTrx-1 – yeast<br />
**[[3f3q]], [[2i9h]] – yTrx-1 – yeast<br />
**[[3f3r]] – yTrx-1 (mutant)<br />
**[[3f3r]] – yTrx-1 (mutant)<br />
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**[[1tk5]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+8-oxo-guanosine<br />
**[[1tk5]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+8-oxo-guanosine<br />
**[[2bto]] – Trx-1+tubulin btuba – ''Prosthecobacter dejongeii''<br />
**[[2bto]] – Trx-1+tubulin btuba – ''Prosthecobacter dejongeii''<br />
-
**[[1oaz]] – Trx-1+immunoglobulin E – rat<br />
 
**[[3tco]] - SsTrx-1 fragment – ''Sulfolobus solfataricus''<br />
**[[3tco]] - SsTrx-1 fragment – ''Sulfolobus solfataricus''<br />
**[[4j57]], [[4j56]] – PfTrx-1 + Trx reductase (mutant)<br />
**[[4j57]], [[4j56]] – PfTrx-1 + Trx reductase (mutant)<br />
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*Thioredoxin F
*Thioredoxin F
 +
**[[1f9m]] – sTrx F <br />
 +
**[[1faa]] - sTrx F (mutant)<br />
**[[2pu9]] – SsTrx F+ferredoxin thioredoxin reductase – Synechocystis<br />
**[[2pu9]] – SsTrx F+ferredoxin thioredoxin reductase – Synechocystis<br />
**[[2pvo]] - SsTrx F+ferredoxin thioredoxin reductase+ferredoxin 1<br />
**[[2pvo]] - SsTrx F+ferredoxin thioredoxin reductase+ferredoxin 1<br />
-
**[[1f9m]] – sTrx F – spinach<br />
 
-
**[[1faa]] - sTrx F (mutant)
 
*Thioredoxin H
*Thioredoxin H
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*Thioredoxin M
*Thioredoxin M
-
**[[2puk]] - SsTrx M+ferredoxin thioredoxin reductase<br />
 
**[[1fb0]], [[1fb6]] - sTrx M<br />
**[[1fb0]], [[1fb6]] - sTrx M<br />
 +
**[[2puk]] - SsTrx M+ferredoxin thioredoxin reductase<br />
**[[1dby]] – CrTrx M – NMR<br />
**[[1dby]] – CrTrx M – NMR<br />
}}
}}

Revision as of 11:15, 20 February 2020

Human thioredoxin (PDB entry 1ert)

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3D Structures of Thioredoxin

Updated on 20-February-2020

References

  1. ↑ Gleason FK, Holmgren A. Thioredoxin and related proteins in procaryotes. FEMS Microbiol Rev. 1988 Dec;4(4):271-97. PMID:3152490
  2. ↑ Sumida Y, Nakashima T, Yoh T, Furutani M, Hirohama A, Kakisaka Y, Nakajima Y, Ishikawa H, Mitsuyoshi H, Okanoue T, Kashima K, Nakamura H, Yodoi J. Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. J Hepatol. 2003 Jan;38(1):32-8. PMID:12480557
  3. ↑ Burke-Gaffney A, Callister ME, Nakamura H. Thioredoxin: friend or foe in human disease? Trends Pharmacol Sci. 2005 Aug;26(8):398-404. PMID:15990177 doi:http://dx.doi.org/10.1016/j.tips.2005.06.005
  4. ↑ Weichsel A, Gasdaska JR, Powis G, Montfort WR. Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer. Structure. 1996 Jun 15;4(6):735-51. PMID:8805557
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