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Thioredoxin

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Line 38: Line 38:
**[[1trs]], [[1tru]], [[1trv]], [[1trw]], [[3trx]], [[4trx]] - hTrx - NMR<br />
**[[1trs]], [[1tru]], [[1trv]], [[1trw]], [[3trx]], [[4trx]] - hTrx - NMR<br />
**[[1xw9]], [[1xwa]], [[1xwb]], [[1xwc]] – Trx – ''Drosophila melanogaster''<br />
**[[1xw9]], [[1xwa]], [[1xwb]], [[1xwc]] – Trx – ''Drosophila melanogaster''<br />
 +
**[[5dbq]] - Trx – velvetbean caterpillar<br />
**[[1gl8]] – sTrx – spinach - NMR<br />
**[[1gl8]] – sTrx – spinach - NMR<br />
**[[3hxs]] – BfTrx fragment – ''Bacteroides fragilis''<br />
**[[3hxs]] – BfTrx fragment – ''Bacteroides fragilis''<br />
Line 87: Line 88:
**[[6ap5]] - Trx – ''Mycobacterium thermoresistibile'' - NMR<br />
**[[6ap5]] - Trx – ''Mycobacterium thermoresistibile'' - NMR<br />
**[[5vo7]] - Trx – ''Mycobacterium smegmatis'' - NMR<br />
**[[5vo7]] - Trx – ''Mycobacterium smegmatis'' - NMR<br />
-
**[[5dbq]] - Trx – velvetbean caterpillar<br />
 
**[[6bkv]] - Trx – ''Helicobacter pylori''<br />
**[[6bkv]] - Trx – ''Helicobacter pylori''<br />
**[[6ckp]] - Trx – ''Brucella melitensis''<br />
**[[6ckp]] - Trx – ''Brucella melitensis''<br />
 +
**[[6nup]] - RpTrx – ''Rickettsia prowazekii''<br />
 +
**[[6mza]] - RpTrx – NMR<br />
 +
**[[6gn9]] – CaTrx – ''Clostridium acetobutylicum''<br />
*Thioredoxin complexes
*Thioredoxin complexes
Line 101: Line 104:
**[[2k9f]] - Trx fragment+DsbD N-terminal – ''Neisseria meningitides'' – NMR<br />
**[[2k9f]] - Trx fragment+DsbD N-terminal – ''Neisseria meningitides'' – NMR<br />
**[[2ipa]] – BsTrx (mutant)+ArcS (mutant) - NMR<br />
**[[2ipa]] – BsTrx (mutant)+ArcS (mutant) - NMR<br />
 +
**[[6gnd]] – CaTrx + Trx reductase <br />
*Thioredoxin 1
*Thioredoxin 1
-
**[[1oaz]] – Trx-1+immunoglobulin E – rat<br />
 
**[[3f3q]], [[2i9h]] – yTrx-1 – yeast<br />
**[[3f3q]], [[2i9h]] – yTrx-1 – yeast<br />
**[[3f3r]] – yTrx-1 (mutant)<br />
**[[3f3r]] – yTrx-1 (mutant)<br />
Line 110: Line 113:
**[[2n5b]] – yTrx-1 (mutant) oxidized<br />
**[[2n5b]] – yTrx-1 (mutant) oxidized<br />
**[[6esx]] - Trx-1 – ''Caulobacter crescentus''<br />
**[[6esx]] - Trx-1 – ''Caulobacter crescentus''<br />
-
**[[3dyr]], [[2h6y]], [[2h6z]], [[2h70]], [[2h71]], [[2h72]], [[2h73]], [[2h74]], [[2h75]], [[2h76]], [[2fch]], [[2fd3]], [[1keb]], [[2eio]], [[2eiq]], [[2eir]], [[1zcp]], [[1zzy]], [[1txx]], [[1tho]], [[4x43]], [[5hr1]] – EcTrx-1 (mutant) <br />
+
**[[3dyr]], [[2h6y]], [[2h6z]], [[2h70]], [[2h71]], [[2h72]], [[2h73]], [[2h74]], [[2h75]], [[2h76]], [[2fch]], [[2fd3]], [[1keb]], [[2eio]], [[2eiq]], [[2eir]], [[1zcp]], [[1zzy]], [[1txx]], [[1tho]], [[4x43]], [[5hr1]], [[6h1y]] – EcTrx-1 (mutant) <br />
 +
**[[3tco]] - SsTrx-1 fragment – ''Sulfolobus solfataricus''<br />
 +
**[[3zl5]] – SmTrx-1 (mutant)<br />
 +
**[[6mos]] – Trx-1 – ''Thermosipho africanus''<br />
 +
**[[6kil]] – Trx-1 (mutant) – ''Halobacterium salinarum''<br />
 +
 
 +
*Thioredoxin 1 complexes
 +
 
 +
**[[1oaz]] – Trx-1+immunoglobulin E – rat<br />
**[[1f6m]] – EcTrx-1+Trx reductase+AADP+<br />
**[[1f6m]] – EcTrx-1+Trx reductase+AADP+<br />
**[[5e4w]] - EcTrx-1 + signal recognition particle + Albino3<br />
**[[5e4w]] - EcTrx-1 + signal recognition particle + Albino3<br />
**[[5ikn]] - EcTrx-1 + T7DNA-directed DNA polymerase + T7DNA primase<br />
**[[5ikn]] - EcTrx-1 + T7DNA-directed DNA polymerase + T7DNA primase<br />
 +
**[[6n7w]] - EcTrx-1 + T7DNA-directed DNA polymerase + DNA <br />
 +
**[[6h7o]], [[6h7n]], [[6h7m]], [[6h7l]], [[6h7j]] - EcTrx-1 (mutant) + adrenergic receptor + antibody<br />
**[[2o8v]] - EcTrx-1 (mutant) + PAPS reductase<br />
**[[2o8v]] - EcTrx-1 (mutant) + PAPS reductase<br />
**[[2ajq]] – EpTrx-1 (mutant)+DNA primer+DNA template+DNA polymerase – Enterobacteria phage T7<br />
**[[2ajq]] – EpTrx-1 (mutant)+DNA primer+DNA template+DNA polymerase – Enterobacteria phage T7<br />
Line 122: Line 135:
**[[1tk5]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+8-oxo-guanosine<br />
**[[1tk5]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+8-oxo-guanosine<br />
**[[2bto]] – Trx-1+tubulin btuba – ''Prosthecobacter dejongeii''<br />
**[[2bto]] – Trx-1+tubulin btuba – ''Prosthecobacter dejongeii''<br />
-
**[[3tco]] - SsTrx-1 fragment – ''Sulfolobus solfataricus''<br />
 
**[[4j57]], [[4j56]] – PfTrx-1 + Trx reductase (mutant)<br />
**[[4j57]], [[4j56]] – PfTrx-1 + Trx reductase (mutant)<br />
-
**[[3zl5]] – SmTrx-1 (mutant)<br />
 
*Thioredoxin 2
*Thioredoxin 2
Line 142: Line 153:
**[[2oe0]], [[2oe1]], [[2oe3]] – yTrx-3<br />
**[[2oe0]], [[2oe1]], [[2oe3]] – yTrx-3<br />
 +
**[[5ykw]] – yTrx-3 + peptide<br />
**[[4xhm]] – Trx-3 – ''Archaeoglobus fulgidus''<br />
**[[4xhm]] – Trx-3 – ''Archaeoglobus fulgidus''<br />
Line 157: Line 169:
**[[2pu9]] – SsTrx F+ferredoxin thioredoxin reductase – Synechocystis<br />
**[[2pu9]] – SsTrx F+ferredoxin thioredoxin reductase – Synechocystis<br />
**[[2pvo]] - SsTrx F+ferredoxin thioredoxin reductase+ferredoxin 1<br />
**[[2pvo]] - SsTrx F+ferredoxin thioredoxin reductase+ferredoxin 1<br />
 +
**[[6i1c]] – CrTrx F2 – ''Chlamydomonas reinhardtii''<br />
*Thioredoxin H
*Thioredoxin H
Line 166: Line 179:
**[[2iwt]] - bTrx H+α-amylase subtilisin inhibitor<br />
**[[2iwt]] - bTrx H+α-amylase subtilisin inhibitor<br />
**[[1wmj]] – Trx H – ''Oryza sativa'' – NMR<br />
**[[1wmj]] – Trx H – ''Oryza sativa'' – NMR<br />
-
**[[1xfl]] – Trx H – ''Arabidopsis thaliana'' - NMR<br />
+
**[[1xfl]] – AtTrx H – ''Arabidopsis thaliana'' - NMR<br />
-
**[[1ep7]] – CrTrx H – ''Chlamydomonas reinhardtii''<br />
+
**[[1ep7]], [[6q47]], [[6q46]], [[6i19]] – CrTrx H<br />
-
**[[1ep8]] - CrTrx H (mutant)<br />
+
**[[1ep8]], [[6q6v]], [[6q6u]], [[6q6t]] - CrTrx H (mutant)<br />
-
**[[1tof]] - CrTrx H - NMR
+
**[[1tof]] - CrTrx H - NMR<br />
 +
**[[5zf2]] – EtTrx H – ''Edwardsiella tarda''<br />
 +
**[[5zpv]] – EtTrx H – NMR<br />
*Thioredoxin M
*Thioredoxin M
Line 176: Line 191:
**[[2puk]] - SsTrx M+ferredoxin thioredoxin reductase<br />
**[[2puk]] - SsTrx M+ferredoxin thioredoxin reductase<br />
**[[1dby]] – CrTrx M – NMR<br />
**[[1dby]] – CrTrx M – NMR<br />
 +
 +
*Thioredoxin O
 +
 +
**[[6g61]] – AtTrx O1 <br />
 +
**[[6g62]] – AtTrx O2 <br />
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:47, 23 February 2020

Human thioredoxin (PDB entry 1ert)

Drag the structure with the mouse to rotate

3D Structures of Thioredoxin

Updated on 23-February-2020

References

  1. ↑ Gleason FK, Holmgren A. Thioredoxin and related proteins in procaryotes. FEMS Microbiol Rev. 1988 Dec;4(4):271-97. PMID:3152490
  2. ↑ Sumida Y, Nakashima T, Yoh T, Furutani M, Hirohama A, Kakisaka Y, Nakajima Y, Ishikawa H, Mitsuyoshi H, Okanoue T, Kashima K, Nakamura H, Yodoi J. Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. J Hepatol. 2003 Jan;38(1):32-8. PMID:12480557
  3. ↑ Burke-Gaffney A, Callister ME, Nakamura H. Thioredoxin: friend or foe in human disease? Trends Pharmacol Sci. 2005 Aug;26(8):398-404. PMID:15990177 doi:http://dx.doi.org/10.1016/j.tips.2005.06.005
  4. ↑ Weichsel A, Gasdaska JR, Powis G, Montfort WR. Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer. Structure. 1996 Jun 15;4(6):735-51. PMID:8805557

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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