Thioredoxin

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</StructureSection>
</StructureSection>
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== 3D Structures of Thioredoxin ==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
 
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*Thioredoxin
 
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**[[1auc]], [[1ert]], [[1eru]] - hTrx - human<br />
 
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**[[3e3e]], [[2hsh]], [[1aiu]], [[1erv]], [[1erw]], [[3m9j]], [[3m9k]], [[4oo4]] – hTrx (mutant) <br />
 
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**[[2hxk]], [[2ifq]], [[2iiy]] – hTrx S-nitroso<br />
 
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**[[4oo5]] - hTrx S-nitroso (mutant)<br />
 
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**[[1auc]], [[1ert]], [[1eru]] - hTrx<br />
 
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**[[5dqy]] – hTrx oxidized<br />
 
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**[[1trs]], [[1tru]], [[1trv]], [[1trw]], [[3trx]], [[4trx]] - hTrx - NMR<br />
 
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**[[1xw9]], [[1xwa]], [[1xwb]], [[1xwc]] – Trx – ''Drosophila melanogaster''<br />
 
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**[[5dbq]] - Trx – velvetbean caterpillar<br />
 
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**[[1gl8]] – sTrx – spinach - NMR<br />
 
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**[[3hxs]] – BfTrx fragment – ''Bacteroides fragilis''<br />
 
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**[[3hyp]] - BfrxI fragment (mutant)<br />
 
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**[[3hz4]] – Trx – ''Methanosarcina mazei''<br />
 
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**[[3die]] – SaTrx (mutant) – ''Staphylococcus aureus''<br />
 
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**[[2voc]] - BsTrx (mutant) – ''Bacillus subtilis''<br />
 
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**[[2gzy]], [[2gzz]] – BsTrx – NMR<br />
 
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**[[2h6x]], [[2trx]], [[1srx]] – EcTrx – ''Escherichia coli''<br />
 
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**[[1xoa]], [[1xob]] – EcTrx - NMR<br />
 
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**[[2tir]], [[4hua]], [[4hu9]], [[4hu7]], [[5hr2]], [[5hr3]], [[5hr0]] - EcTrx (mutant) <br />
 
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**[[1m7t]] – hTrx/EcTrx chimera - NMR<br />
 
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**[[3emx]] – Trx – ''Aeropyrum pernix''<br />
 
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**[[2vim]] – Trx – ''Fasciola hepatica''<br />
 
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**[[2yzu]], [[2cvk]], [[1v98]], [[4tn8]] – TtTrx – ''Thermus thermophilus''<br />
 
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**[[2lst]] – TtTrx - NMR<br />
 
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**[[2e0q]] – Trx (mutant) – ''Sulfolobus tokodaii''<br />
 
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**[[2o7k]] – SaTrx<br />
 
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**[[2o85]], [[2o87]], [[2o89]] – SaTrx (mutant)<br />
 
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**[[2i4a]] – Trx – ''Acetobacter aceti''<br />
 
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**[[2j23]] – Trx – ''Malassezia sympodialis''<br />
 
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**[[2f51]] – Trx – ''Trichomonas vaginalis''<br />
 
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**[[1t00]] – Trx – ''Streptomyces coelicolor''<br />
 
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**[[1rqm]], [[1nsw]], [[1nw2]] – Trx (mutant) – ''Alicyclobacillus acidocaldarius'' – NMR<br />
 
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**[[1syr]] – PfTrx – ''Plasmodium falciparum''<br />
 
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**[[2mmn]], [[2mmo]] - PfTrx - NMR<br />
 
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**[[1r26]] – Trx – ''Trypanosoma brucei brucei''<br />
 
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**[[1fo5]] – Trx – ''Methanocaldococcus janaschii'' – NMR<br />
 
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**[[1quw]] – Trx – ''Bacillus acidocaldarius'' – NMR<br />
 
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**[[2l5l]] – Trx – ''Bacteroides vulgatus'' – NMR<br />
 
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**[[2xbi]] – SmTrx – ''Schistosoma mansoni''<br />
 
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**[[2xbq]], [[2xc2]] – SmTrx (mutant)<br />
 
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**[[4i8b]] - Trx – ''Schistosoma japonicum''<br />
 
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**[[3zzx]], [[4aj8]], [[4aj7]], [[4aj6]], [[4v2l]], [[4v2m]], [[4v2n]] – LvTrx – ''Litopenaeus vannamei''<br />
 
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**[[5hr0]] - LvTrx (mutant) <br />
 
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**[[4fyu]] – Trx – ''Wuchereria bancrofti''<br />
 
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**[[4knd]] – Trx – ''Anaeromyxobacter dehalogenans''<br />
 
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**[[3vfi]] – Trx – Silicabacter phage dss3ϕ2<br />
 
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**[[3zij]] – BcTrx – ''Bacillus cereus''<br />
 
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**[[3zit]] - BcTrx (mutant)<br />
 
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**[[2k8s]] – Trx – ''Nitrosomonas europaea'' - NMR<br />
 
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**[[2l6c]], [[2l6d]] – Trx – ''Desulfovibrio vulgaris'' - NMR<br />
 
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**[[2yj7]], [[2yn1]], [[2yoi]], [[2ypm]], [[3ziv]], [[4ba7]] – ancestral Trx – synthetic<br />
 
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**[[4pob]] – Trx – ''Mycobacterium abscessus''<br />
 
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**[[2ynx]], [[4ulx]] – Trx – Last Archaea Common Ancestor<br />
 
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**[[4cw9]] - Trx (mutant) – ''Entamoeba histolytica''<br />
 
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**[[4wxt]] - Trx – ''Mycobacterium avium''<br />
 
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**[[5jy5]] - Trx – ''Cryptococcus neoformans''<br />
 
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**[[6ap5]] - Trx – ''Mycobacterium thermoresistibile'' - NMR<br />
 
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**[[5vo7]] - Trx – ''Mycobacterium smegmatis'' - NMR<br />
 
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**[[6bkv]] - Trx – ''Helicobacter pylori''<br />
 
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**[[6ckp]] - Trx – ''Brucella melitensis''<br />
 
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**[[6nup]] - RpTrx – ''Rickettsia prowazekii''<br />
 
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**[[6mza]] - RpTrx – NMR<br />
 
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**[[6gn9]] – CaTrx – ''Clostridium acetobutylicum''<br />
 
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*Thioredoxin complexes
 
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**[[3kd0]] - hTrx (mutant)+CdCl2<br />
 
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**[[4pok]], [[4pol]], [[4pom]] - hTrx (mutant)+ thioethanesulfonate<br />
 
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**[[4puf]] - hTrx (mutant)+ E3 ubiquitin-protein ligase<br />
 
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**[[1cqg]], [[1cqh]] - hTrx (mutant)+Ref-1 peptide – NMR<br />
 
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**[[1mdi]], [[1mdj]], [[1mdk]] - hTrx + Target peptide of NFKB – NMR<br />
 
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**[[3dxb]] – hTrx+Puf60 C-terminal<br />
 
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**[[2k9f]] - Trx fragment+DsbD N-terminal – ''Neisseria meningitides'' – NMR<br />
 
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**[[2ipa]] – BsTrx (mutant)+ArcS (mutant) - NMR<br />
 
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**[[6gnd]] – CaTrx + Trx reductase <br />
 
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*Thioredoxin 1
 
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**[[3f3q]], [[2i9h]] – yTrx-1 – yeast<br />
 
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**[[3f3r]] – yTrx-1 (mutant)<br />
 
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**[[2n5a]] – yTrx-1 (mutant) reduced<br />
 
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**[[2n5b]] – yTrx-1 (mutant) oxidized<br />
 
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**[[6esx]] - Trx-1 – ''Caulobacter crescentus''<br />
 
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**[[3dyr]], [[2h6y]], [[2h6z]], [[2h70]], [[2h71]], [[2h72]], [[2h73]], [[2h74]], [[2h75]], [[2h76]], [[2fch]], [[2fd3]], [[1keb]], [[2eio]], [[2eiq]], [[2eir]], [[1zcp]], [[1zzy]], [[1txx]], [[1tho]], [[4x43]], [[5hr1]], [[6h1y]] – EcTrx-1 (mutant) <br />
 
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**[[3tco]] - SsTrx-1 fragment – ''Sulfolobus solfataricus''<br />
 
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**[[3zl5]] – SmTrx-1 (mutant)<br />
 
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**[[6mos]] – Trx-1 – ''Thermosipho africanus''<br />
 
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**[[6kil]] – Trx-1 (mutant) – ''Halobacterium salinarum''<br />
 
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*Thioredoxin 1 complexes
 
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**[[1oaz]] – Trx-1+immunoglobulin E – rat<br />
 
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**[[1f6m]] – EcTrx-1+Trx reductase+AADP+<br />
 
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**[[5e4w]] - EcTrx-1 + signal recognition particle + Albino3<br />
 
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**[[5ikn]] - EcTrx-1 + T7DNA-directed DNA polymerase + T7DNA primase<br />
 
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**[[6n7w]] - EcTrx-1 + T7DNA-directed DNA polymerase + DNA <br />
 
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**[[6h7o]], [[6h7n]], [[6h7m]], [[6h7l]], [[6h7j]] - EcTrx-1 (mutant) + adrenergic receptor + antibody<br />
 
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**[[2o8v]] - EcTrx-1 (mutant) + PAPS reductase<br />
 
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**[[2ajq]] – EpTrx-1 (mutant)+DNA primer+DNA template+DNA polymerase – Enterobacteria phage T7<br />
 
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**[[1zyq]] – EpTrx-1 (mutant)+DNA primer+DNA template+DNA polymerase+ATP<br />
 
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**[[1x9m]], [[1x9s]], [[1x9w]] – EpTrx-1+DNA primer+DNA template+DNA polymerase+N-2-acetylaminofluorene-adducted DNA<br />
 
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**[[1t8e]], [[1skr]], [[1sks]], [[1skw]], [[1sl0]], [[1sl1]], [[1sl2]], [[1t7p]] – EpTrx-1 +DNA primer+DNA template+DNA polymerase+dCTP<br />
 
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**[[1tk0]], [[1tk8]], [[1tkd]] – EpTrx-1+DNA primer+DNA template+DNA polymerase+ nucleotide +8-oxo-guanosine<br />
 
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**[[1tk5]] - EpTrx-1+DNA primer+DNA template+DNA polymerase+8-oxo-guanosine<br />
 
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**[[2bto]] – Trx-1+tubulin btuba – ''Prosthecobacter dejongeii''<br />
 
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**[[4j57]], [[4j56]] – PfTrx-1 + Trx reductase (mutant)<br />
 
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*Thioredoxin 2
 
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**[[1w4v]], [[1w89]], [[1uvz]] – hTrx-2 <br />
 
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**[[3hhv]] – SsTrx-2 fragment <br />
 
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**[[2fa4]] – yTrx-2<br />
 
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**[[2hsy]] – yTrx-2 - NMR<br />
 
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**[[3pin]] - yTrx-2+peptide methionine sulfoxide reductase<br />
 
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**[[4dss]] – yTrx-2 + peroxiredoxin-2<br />
 
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**[[2ppt]] – Trx-2 – ''Rhodobacter capsulatus''<br />
 
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**[[1thx]] – Trx-2 – Anabaena<br />
 
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**[[3ul3]], [[4o32]] – PfTrx-2<br />
 
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**[[4ruv]] – SaTrx-2 <br />
 
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*Thioredoxin 3
 
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**[[2oe0]], [[2oe1]], [[2oe3]] – yTrx-3<br />
 
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**[[5ykw]] – yTrx-3 + peptide<br />
 
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**[[4xhm]] – Trx-3 – ''Archaeoglobus fulgidus''<br />
 
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*Thioredoxin C
 
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**[[2i1u]] – MtTrx C – ''Mycobacterium tuberculosis''<br />
 
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**[[2l4q]], [[2l59]] – MtTrx C - NMR<br />
 
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**[[3nof]] – MtTrx (mutant)<br />
 
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**[[3o6t]] – MtTrx (mutant)+quinol
 
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*Thioredoxin F
 
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**[[1f9m]] – sTrx F <br />
 
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**[[1faa]] - sTrx F (mutant)<br />
 
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**[[2pu9]] – SsTrx F+ferredoxin thioredoxin reductase – Synechocystis<br />
 
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**[[2pvo]] - SsTrx F+ferredoxin thioredoxin reductase+ferredoxin 1<br />
 
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**[[6i1c]] – CrTrx F2 – ''Chlamydomonas reinhardtii''<br />
 
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*Thioredoxin H
 
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**[[3d21]] – pTrx H – poplar<br />
 
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**[[3d22]] - pTrx H (mutant)<br />
 
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**[[1ti3]] - pTrx H - NMR<br />
 
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**[[2vlt]], [[2vlu]], [[2vlv]], [[2vm1]], [[2vm2]] - bTrx H – barley<br />
 
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**[[2iwt]] - bTrx H+α-amylase subtilisin inhibitor<br />
 
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**[[1wmj]] – Trx H – ''Oryza sativa'' – NMR<br />
 
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**[[1xfl]] – AtTrx H – ''Arabidopsis thaliana'' - NMR<br />
 
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**[[1ep7]], [[6q47]], [[6q46]], [[6i19]] – CrTrx H<br />
 
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**[[1ep8]], [[6q6v]], [[6q6u]], [[6q6t]] - CrTrx H (mutant)<br />
 
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**[[1tof]] - CrTrx H - NMR<br />
 
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**[[5zf2]] – EtTrx H – ''Edwardsiella tarda''<br />
 
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**[[5zpv]] – EtTrx H – NMR<br />
 
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*Thioredoxin M
 
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**[[1fb0]], [[1fb6]] - sTrx M<br />
 
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**[[2puk]] - SsTrx M+ferredoxin thioredoxin reductase<br />
 
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**[[1dby]] – CrTrx M – NMR<br />
 
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*Thioredoxin O
 
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**[[6g61]] – AtTrx O1 <br />
 
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**[[6g62]] – AtTrx O2 <br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:48, 23 February 2020

Human thioredoxin (PDB entry 1ert)

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References

  1. ↑ Gleason FK, Holmgren A. Thioredoxin and related proteins in procaryotes. FEMS Microbiol Rev. 1988 Dec;4(4):271-97. PMID:3152490
  2. ↑ Sumida Y, Nakashima T, Yoh T, Furutani M, Hirohama A, Kakisaka Y, Nakajima Y, Ishikawa H, Mitsuyoshi H, Okanoue T, Kashima K, Nakamura H, Yodoi J. Serum thioredoxin levels as a predictor of steatohepatitis in patients with nonalcoholic fatty liver disease. J Hepatol. 2003 Jan;38(1):32-8. PMID:12480557
  3. ↑ Burke-Gaffney A, Callister ME, Nakamura H. Thioredoxin: friend or foe in human disease? Trends Pharmacol Sci. 2005 Aug;26(8):398-404. PMID:15990177 doi:http://dx.doi.org/10.1016/j.tips.2005.06.005
  4. ↑ Weichsel A, Gasdaska JR, Powis G, Montfort WR. Crystal structures of reduced, oxidized, and mutated human thioredoxins: evidence for a regulatory homodimer. Structure. 1996 Jun 15;4(6):735-51. PMID:8805557
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