Thymidylate kinase
From Proteopedia
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</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of thymidylate kinase == | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Thymidylate kinase | ||
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| - | **[[2cck]], [[4f4i]] – SaTMK – ''Staphylococcus aureus'' <br /> | ||
| - | **[[2pbr]], [[4s2e]], [[5h5b]] – AaTMK – ''Aquifex aeolicus'' <br /> | ||
| - | **[[5xb5]], [[5xbh]] – AaTMK (mutant) <br /> | ||
| - | **[[2plr]] – TMK – ''Sulfolobus tokodaii'' <br /> | ||
| - | **[[3ld9]] – TMK – ''Ehrlichia chafeensis''<br /> | ||
| - | **[[3v9p]] – TMK – ''Burkholderia thailandensis''<br /> | ||
| - | **[[3uwk]], [[3uwo]] – PaTMK – ''Pseudomonas aeruginosa''<br /> | ||
| - | **[[5x7j]], [[5xak]], [[5xt8]] – TtTMK – ''Thermus thermophilus''<br /> | ||
| - | **[[5x8d]], [[5x8j]], [[5x8k]], [[5x8v]], [[5x98]], [[5x99]], [[5xal]] – TtTMK (mutant)<br /> | ||
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| - | *Thymidylate kinase complex with HIV prodrug AZT derivative | ||
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| - | **[[1e98]], [[1e99]], [[1e9d]] – hTMK (mutant) + AZTP + ADP - human<br /> | ||
| - | **[[2tmk]] – yTMK + AZTP <br /> | ||
| - | **[[4eaq]] – SaTMK + AZTP <br /> | ||
| - | **[[4gmd]] – PaTMK + AZTP <br /> | ||
| - | **[[4tmk]], [[5tmp]] – TMK + AZTP – ''Escherichia coli''<br /> | ||
| - | **[[1w2h]] – MtTMK + AZTP - ''Mycobacterium tuberculosis'' <br /> | ||
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| - | *Thymidylate kinase complex with one nucleotide | ||
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| - | **[[1tmk]] – yTMK + dTMP - yeast<br /> | ||
| - | **[[2v54]] – VvTMK + TDP – Vaccinia virus<br /> | ||
| - | **[[2w0s]] – VvTMK + brivudin-MP <br /> | ||
| - | **[[4e5u]] – PaTMK + dTMP <br /> | ||
| - | **[[3uxm]], [[4esh]] – PaTMK + deoxy thymidine derivative <br /> | ||
| - | **[[2ccg]], [[2ccj]], [[4dwj]] – SaTMK + dTMP <br /> | ||
| - | **[[1g3u]], [[1gsi]], [[1n5i]], [[1n5k]] – MtTMK + dTMP <br /> | ||
| - | **[[1w2g]] – MtTMK + thymidine <br /> | ||
| - | **[[1gtv]] – MtTMK + TDP <br /> | ||
| - | **[[1mrs]] – MtTMK + UMP derivative <br /> | ||
| - | **[[2yof]], [[2yog]], [[2yoh]] - TMK + thymidine analog – ''Plasmodium falciparum''<br /> | ||
| - | **[[5xai]] – AaTMK + TMP <br /> | ||
| - | **[[5x86]] – TtTMK + dTMP <br /> | ||
| - | **[[5x8a]] – TtTMK + ATP <br /> | ||
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| - | *Thymidylate kinase complex with two nucleotides | ||
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| - | **[[1e2d]], [[1e2e]], [[1e2f]], [[1e9e]], [[1e9f]] – hTMK (mutant) + ADP + dTMP<br /> | ||
| - | **[[1e2q]] – hTMK (mutant) + ATP + dTMP<br /> | ||
| - | **[[1e9f]] – hTMK (mutant) + ADP + dTMP<br /> | ||
| - | **[[1e9b]] – hTMK (mutant) + azido-TMP + APPNP<br /> | ||
| - | **[[1e9c]] – hTMK (mutant) + dTMP + APPNP<br /> | ||
| - | **[[1nmx]] – hTMK (mutant) + F-TMP + ADP<br /> | ||
| - | **[[1nmy]], [[1nn0]], [[1nnz]], [[1nn1]], [[1nn3]], [[1nn5]], [[1nmz]] – hTMK (mutant) + dTMP derivative + APPNP<br /> | ||
| - | **[[2xx3]] – hTMK + dTMP derivative + ADP<br />> | ||
| - | **[[4edh]] – PaTMK + ADP + dTMP <br /> | ||
| - | **[[1n5j]] – MtTMK + TDP + TTP<br /> | ||
| - | **[[1n5l]] – MtTMK + TDP + dTMP <br /> | ||
| - | **[[3hjn]] – TMK + ADP + TDP – ''Thermotoga maritima''<br /> | ||
| - | **[[3lv8]] – VcTMK + ADP + dTMP + TDP – ''Vibrio cholerae''<br /> | ||
| - | **[[3n2i]] – VcTMK + thymidine + thymidine deoxy-thymidine<br /> | ||
| - | **[[4s35]] – AaTMK + dTMP + AMPPCP<br /> | ||
| - | **[[5h56]] – AaTMK + dTDP + ADP<br /> | ||
| - | **[[5xb2]], [[5xb3]] – AaTMK + dTMP + ADP<br /> | ||
| - | **[[5h5k]] – AaTMK + CMP + ATP<br /> | ||
| - | **[[5uiv]] - TMK + TMP + ADP – ''Candida albicans''<br /> | ||
| - | **[[5x8b]] – TtTMK + TMP + ADP + ATP <br /> | ||
| - | **[[5zax]] – TtTMK + TMP + ADP + TDP <br /> | ||
| - | **[[5zb0]] – TtTMK + ADP + TDP <br /> | ||
| - | **[[5zb4]] – TtTMK + ADP + TMP <br /> | ||
| - | **[[5x8c]] – TtTMK + dTMP + AMPPCP<br /> | ||
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| - | *Other thymidylate kinase binary complexes | ||
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| - | **[[4gfd]], [[4hlc]], [[4hld]], [[4hej]], [[4hdc]] – SaTMK + antibacterial drug <br /> | ||
| - | **[[4gsy]], [[4qg7]], [[4xwa]] – SaTMK + inhibitor<br /> | ||
| - | **[[4qg7]], [[4qgf]], [[4qgg]], [[4qgh]], [[4qga]] – SaTMK (mutant) + inhibitor<br /> | ||
| - | **[[4mqb]] – SaTMK + MES<br /> | ||
| - | **[[4unp]], [[4unq]], [[4unn]], [[4unr]], [[4uns]] – MtTMK + inhibitor<br /> | ||
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| - | *Thymidylate kinase complex with bisubstrate inhibitor | ||
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| - | **[[1mrn]] – MtTMK + TP5A <br /> | ||
| - | **[[3tmk]] – yTMK + TP5A <br /> | ||
| - | **[[1e9a]] – hTMK (mutant) + azido-TP5A + ADP<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Cui Q, Shin WS, Luo Y, Tian J, Cui H, Yin D. Thymidylate kinase: an old topic brings new perspectives. Curr Med Chem. 2013;20(10):1286-305. PMID:23394555
- ↑ Wohrl BM, Loubiere L, Brundiers R, Goody RS, Klatzmann D, Konrad M. Expressing engineered thymidylate kinase variants in human cells to improve AZT phosphorylation and human immunodeficiency virus inhibition. J Gen Virol. 2005 Mar;86(Pt 3):757-64. PMID:15722537 doi:http://dx.doi.org/10.1099/vir.0.80529-0
- ↑ Martinez-Botella G, Breen JN, Duffy JE, Dumas J, Geng B, Gowers IK, Green OM, Guler S, Hentemann MF, Hernandez-Juan FA, Joseph-McCarthy D, Kawatkar SP, Larsen NA, Lazari O, Loch JT, Macritchie JA, McKenzie AR, Newman JV, Olivier NB, Otterson LG, Owens AP, Read J, Sheppard DW, Keating TA. Discovery of Selective and Potent Inhibitors of Gram-positive Bacterial Thymidylate Kinase (TMK). J Med Chem. 2012 Oct 8. PMID:23043329 doi:http://dx.doi.org/10.1021/jm3011806
- ↑ Ostermann N, Lavie A, Padiyar S, Brundiers R, Veit T, Reinstein J, Goody RS, Konrad M, Schlichting I. Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP. J Mol Biol. 2000 Nov 17;304(1):43-53. PMID:11071809 doi:10.1006/jmbi.2000.4175
