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1akd

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[[Image:1akd.gif|left|200px]]
[[Image:1akd.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1akd |SIZE=350|CAPTION= <scene name='initialview01'>1akd</scene>, resolution 1.8&Aring;
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The line below this paragraph, containing "STRUCTURE_1akd", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=HEM:Heme+Binding+Site'>HEM</scene> and <scene name='pdbsite=K:K++Binding+Site'>K</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CAM:CAMPHOR'>CAM</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Camphor_5-monooxygenase Camphor 5-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.15.1 1.14.15.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1akd| PDB=1akd | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1akd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1akd OCA], [http://www.ebi.ac.uk/pdbsum/1akd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1akd RCSB]</span>
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}}
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'''CYTOCHROME P450CAM FROM PSEUDOMONAS PUTIDA, COMPLEXED WITH 1S-CAMPHOR'''
'''CYTOCHROME P450CAM FROM PSEUDOMONAS PUTIDA, COMPLEXED WITH 1S-CAMPHOR'''
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[[Category: Schlichting, I.]]
[[Category: Schlichting, I.]]
[[Category: Schulze, H.]]
[[Category: Schulze, H.]]
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[[Category: cytochrome p450]]
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[[Category: Cytochrome p450]]
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[[Category: electron transport]]
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[[Category: Electron transport]]
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[[Category: monooxygenase]]
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[[Category: Monooxygenase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: oxygenase]]
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[[Category: Oxygenase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:22:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:42:06 2008''
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Revision as of 07:22, 2 May 2008

Image:1akd.gif

Template:STRUCTURE 1akd

CYTOCHROME P450CAM FROM PSEUDOMONAS PUTIDA, COMPLEXED WITH 1S-CAMPHOR


Overview

The crystal structure of cytochrome P-450cam complexed with the enantiomer (1S)-camphor has been solved to 1.8 angstroms resolution and compared with the structure of the (1R)-camphor P-450cam complex. The overall protein structure is the same for both enantiomer complexes. However, the orientation of the substrates in the heme pocket differs. In contrast to (1R)-camphor, the (1S)-enantiomer binds in at least two orientations. The major binding mode of (1S)-camphor resembles the one of the (1R)-enantiomer in that there is a hydrogen bond between Tyr-96 and the quinone group of camphor, and the 10-methyl group points towards the I-helix. The binding differs in that C-5 is not at a position suitable for hydroxylation. In the other orientation (1S)-camphor is not hydrogen bonded, but C-5 is located suitably for hydroxylation.

About this Structure

1AKD is a Single protein structure of sequence from Pseudomonas putida. Full crystallographic information is available from OCA.

Reference

Crystal structure of cytochrome P-450cam complexed with the (1S)-camphor enantiomer., Schlichting I, Jung C, Schulze H, FEBS Lett. 1997 Oct 6;415(3):253-7. PMID:9357977 Page seeded by OCA on Fri May 2 10:22:58 2008

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