6li2

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'''Unreleased structure'''
 
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The entry 6li2 is ON HOLD until Paper Publication
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==Crystal structure of GPR52 ligand free form with rubredoxin fusion==
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<StructureSection load='6li2' size='340' side='right'caption='[[6li2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6li2]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LI2 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6li2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6li2 OCA], [http://pdbe.org/6li2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6li2 RCSB], [http://www.ebi.ac.uk/pdbsum/6li2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6li2 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/GPR52_HUMAN GPR52_HUMAN]] Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228).<ref>PMID:24587241</ref> <ref>PMID:25738228</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Han, G W]]
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[[Category: Lin, X]]
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[[Category: Luo, Z P]]
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[[Category: Xu, F]]
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[[Category: Apo form]]
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[[Category: Class some]]
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[[Category: Human gpr52 receptor]]
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[[Category: Lcp]]
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[[Category: Membrane protein]]
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[[Category: Orphan gpcr]]
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[[Category: Rubredoxin]]

Revision as of 09:14, 26 February 2020

Crystal structure of GPR52 ligand free form with rubredoxin fusion

PDB ID 6li2

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