6vja
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of CD20 in complex with rituximab Fab== | |
| - | + | <StructureSection load='6vja' size='340' side='right'caption='[[6vja]], [[Resolution|resolution]] 3.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6vja]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VJA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6VJA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6vja FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vja OCA], [http://pdbe.org/6vja PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vja RCSB], [http://www.ebi.ac.uk/pdbsum/6vja PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vja ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CD20_HUMAN CD20_HUMAN]] Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:[http://omim.org/entry/613495 613495]]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.<ref>PMID:20038800</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CD20_HUMAN CD20_HUMAN]] This protein may be involved in the regulation of B-cell activation and proliferation. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Croll, T I]] | ||
| + | [[Category: Rohou, A]] | ||
| + | [[Category: Antibody]] | ||
| + | [[Category: Cd20]] | ||
| + | [[Category: Human]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Ms4a1]] | ||
| + | [[Category: Rituximab]] | ||
| + | [[Category: Therapeutic]] | ||
Revision as of 09:28, 26 February 2020
Structure of CD20 in complex with rituximab Fab
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Categories: Large Structures | Croll, T I | Rohou, A | Antibody | Cd20 | Human | Immune system | Ms4a1 | Rituximab | Therapeutic
