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1akz

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[[Image:1akz.gif|left|200px]]
[[Image:1akz.gif|left|200px]]
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{{Structure
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{{STRUCTURE_1akz| PDB=1akz | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1akz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1akz OCA], [http://www.ebi.ac.uk/pdbsum/1akz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1akz RCSB]</span>
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'''HUMAN URACIL-DNA GLYCOSYLASE'''
'''HUMAN URACIL-DNA GLYCOSYLASE'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Tainer, C D.M J.A.]]
[[Category: Tainer, C D.M J.A.]]
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[[Category: alpha/ beta protein]]
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[[Category: Alpha/ beta protein]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: glycosidase]]
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[[Category: Glycosidase]]
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[[Category: glycosylase]]
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[[Category: Glycosylase]]
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[[Category: uracil removal from dna]]
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[[Category: Uracil removal from dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:24:23 2008''
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Revision as of 07:24, 2 May 2008

Image:1akz.gif

Template:STRUCTURE 1akz

HUMAN URACIL-DNA GLYCOSYLASE


Overview

Crystal structures of the DNA repair enzyme human uracil-DNA glycosylase (UDG), combined with mutational analysis, reveal the structural basis for the specificity of the enzyme. Within the classic alpha/beta fold of UDG, sequence-conserved residues form a positively charged, active-site groove the width of duplex DNA, at the C-terminal edge of the central four-stranded parallel beta sheet. In the UDG-6-aminouracil complex, uracil binds at the base of the groove within a rigid preformed pocket that confers selectivity for uracil over other bases by shape complementary and by main chain and Asn-204 side chain hydrogen bonds. Main chain nitrogen atoms are positioned to stabilize the oxyanion intermediate generated by His-268 acting via nucleophilic attack or general base mechanisms. Specific binding of uracil flipped out from a DNA duplex provides a structural mechanism for damaged base recognition.

About this Structure

1AKZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis., Mol CD, Arvai AS, Slupphaug G, Kavli B, Alseth I, Krokan HE, Tainer JA, Cell. 1995 Mar 24;80(6):869-78. PMID:7697717 Page seeded by OCA on Fri May 2 10:24:23 2008

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