TIR domain-containing adapter protein

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<StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain complex with dithiothreitol (PDB code [[3ub2]])' scene=''>
<StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain complex with dithiothreitol (PDB code [[3ub2]])' scene=''>
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'''TIR domain-containing adaptor protein''' (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: '''MyD88, MAL, TRIF, TRAM and SARM'''. The TIR domain, which is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein<ref>PMID:17457343</ref>. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response.
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'''TIR domain-containing adaptor protein''' or '''Toll/Interleukin-1 receptor domain-containing adaptor protein''' (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: '''MyD88, MAL, TRIF, TRAM and SARM'''. The TIR domain, which is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein<ref>PMID:17457343</ref>. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response.
</StructureSection>
</StructureSection>
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**[[2m1w]], [[2m1x]], [[2ndh]] – hMAL TIR domain (mutant) - NMR<br />
**[[2m1w]], [[2m1x]], [[2ndh]] – hMAL TIR domain (mutant) - NMR<br />
**[[2m63]] – hMAL N-terminal domain - NMR<br />
**[[2m63]] – hMAL N-terminal domain - NMR<br />
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**[[5t7q]] – hMAL residues 15-35 - NMR<br />
*MyD88
*MyD88

Revision as of 09:59, 26 February 2020

MAL adaptor protein TIR domain complex with dithiothreitol (PDB code 3ub2)

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3D Structures of TIR domain-containing adaptor protein

Updated on 26-February-2020


References

  1. ↑ O'Neill LA, Bowie AG. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol. 2007 May;7(5):353-64. PMID:17457343 doi:http://dx.doi.org/nri2079

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Michal Harel, Alexander Berchansky, Jaime Prilusky

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