4unr
From Proteopedia
(Difference between revisions)
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==Mtb TMK in complex with compound 23== | ==Mtb TMK in complex with compound 23== | ||
| - | <StructureSection load='4unr' size='340' side='right' caption='[[4unr]], [[Resolution|resolution]] 1.98Å' scene=''> | + | <StructureSection load='4unr' size='340' side='right'caption='[[4unr]], [[Resolution|resolution]] 1.98Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4unr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UNR FirstGlance]. <br> | <table><tr><td colspan='2'>[[4unr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UNR FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QZE:4-[3-CYANO-2-OXO-7-(1H-PYRAZOL-4-YL)-5,6-DIHYDRO-1H-BENZO[H]QUINOLIN-4-YL]BENZOIC+ACID'>QZE</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QZE:4-[3-CYANO-2-OXO-7-(1H-PYRAZOL-4-YL)-5,6-DIHYDRO-1H-BENZO[H]QUINOLIN-4-YL]BENZOIC+ACID'>QZE</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4unn|4unn]], [[4unp|4unp]], [[4unq|4unq]], [[4uns|4uns]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4unn|4unn]], [[4unp|4unp]], [[4unq|4unq]], [[4uns|4uns]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tmk, tmk_1, tmk_2, DKC2_3451, DSI35_30710, ERS007657_00125, ERS007661_00085, ERS007679_02297, ERS007681_01491, ERS007703_02607, ERS007741_01144, ERS023446_00222, ERS024213_00798, ERS027644_01165, ERS027646_01076, ERS027651_00812, ERS027652_02895, ERS027653_00561, ERS027654_03560, ERS027656_02366, ERS027659_02658, ERS027666_03206, ERS031537_04492, ERS124361_01566, EU767_17775, EU768_12605, EU769_05785, EU770_08300, EU771_12795, EU773_12630, EU774_05685, EU775_05915, EU776_12880, EU777_03925, EUB02_06795, EUB03_06915, EUB06_16595, EUB07_02595, EUB08_14260, EUB09_06965, EUB10_01690, EUB11_02810, EUB12_02780, EUB13_09520, EUB14_09750, EUB16_09100, SAMEA2682835_07050, SAMEA2683035_03767 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/dTMP_kinase dTMP kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.9 2.7.4.9] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4unr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4unr OCA], [http://pdbe.org/4unr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4unr RCSB], [http://www.ebi.ac.uk/pdbsum/4unr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4unr ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4unr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4unr OCA], [http://pdbe.org/4unr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4unr RCSB], [http://www.ebi.ac.uk/pdbsum/4unr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4unr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A0A045HB39_MYCTX A0A045HB39_MYCTX]] Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.[HAMAP-Rule:MF_00165] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
| - | *[[Thymidylate kinase|Thymidylate kinase]] | + | *[[Thymidylate kinase 3D structures|Thymidylate kinase 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: DTMP kinase]] | [[Category: DTMP kinase]] | ||
[[Category: Gingell, H]] | [[Category: Gingell, H]] | ||
Revision as of 10:43, 26 February 2020
Mtb TMK in complex with compound 23
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