1alu

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[[Image:1alu.gif|left|200px]]
[[Image:1alu.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1alu", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>
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{{STRUCTURE_1alu| PDB=1alu | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1alu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alu OCA], [http://www.ebi.ac.uk/pdbsum/1alu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1alu RCSB]</span>
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'''HUMAN INTERLEUKIN-6'''
'''HUMAN INTERLEUKIN-6'''
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[[Category: Somers, W S.]]
[[Category: Somers, W S.]]
[[Category: Stahl, M.]]
[[Category: Stahl, M.]]
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[[Category: cytokine]]
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[[Category: Cytokine]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: interleukin]]
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[[Category: Interleukin]]
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[[Category: receptor]]
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[[Category: Receptor]]
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[[Category: signaling]]
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[[Category: Signaling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:25:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:42:59 2008''
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Revision as of 07:25, 2 May 2008

Image:1alu.gif

Template:STRUCTURE 1alu

HUMAN INTERLEUKIN-6


Overview

Interleukin 6 (IL-6) has many biological activities in vivo, and deregulation has been implicated in many disease processes. IL-6, a 185 amino acid polypeptide was refolded, purified and crystallized. The crystals diffracted to beyond 1.9 A and the structure was solved using single isomorphous replacement. The X-ray structure of IL-6 is composed of a four helix bundle linked by loops and an additional mini-helix. 157 out of 185 residues are well defined in the final structure, with 18 N-terminal and 8 A-B loop amino acids displaying no interpretable electron density. The three-dimensional structure has been used to construct a model of IL-6 interacting with the IL-6 receptor (alpha-chain) and gp130 (beta-chain) that gives new insight into the process of molecular recognition and signaling. Based on this model, we predict a fourth binding site on IL-6, a low affinity IL-6-IL-6 interaction, which may be necessary for the sequential assembly of a functional hexameric IL-6 receptor complex.

About this Structure

1ALU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

1.9 A crystal structure of interleukin 6: implications for a novel mode of receptor dimerization and signaling., Somers W, Stahl M, Seehra JS, EMBO J. 1997 Mar 3;16(5):989-97. PMID:9118960 Page seeded by OCA on Fri May 2 10:25:47 2008

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