TNF receptor-associated factor

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== Structural highlights ==
== Structural highlights ==
The interaction of TRAF2 with the adaptor protein TRADD is <scene name='70/708054/Cv/4'>bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions</scene><ref>PMID:10892748</ref>. {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}
The interaction of TRAF2 with the adaptor protein TRADD is <scene name='70/708054/Cv/4'>bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions</scene><ref>PMID:10892748</ref>. {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}
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== 3D Structures of TNF receptor-associated factor ==
 +
[[TNF receptor-associated factor 3D structures]]
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</StructureSection>
</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*TRAF1
+
*TRAF1; domains – RING 66-124; zinc finger 1-3 125-211; ZF-TRAF 190-248; TRAF 348-504
**[[5e1t]] – hTRAF1 TRAF domain - human<br />
**[[5e1t]] – hTRAF1 TRAF domain - human<br />
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*TRAF3
*TRAF3
 +
**[[2ecy]] – hTRAF3 RING domain - NMR<br />
 +
**[[1flk]] – hTRAF3 TRAF domain<br />
 +
**[[2gkw]] – hTRAF3 TRAF domain + BAFF receptor peptide <br />
 +
**[[1zms]] – hTRAF3 TRAF domain + LMP1 peptide <br />
 +
**[[1rf3]] – hTRAF3 TRAF domain + lymphotoxin receptor peptide <br />
 +
**[[1kzz]] – hTRAF3 TRAF domain + TANK peptide <br />
 +
**[[1l0a]] – hTRAF3 TRAF domain (mutant) + TANK peptide <br />
 +
**[[1fll]] – hTRAF3 TRAF domain + CD40 peptide <br />
**[[4ghu]] – TRAF3 TRAF domain + antiviral-signaling protein peptide - mouse <br />
**[[4ghu]] – TRAF3 TRAF domain + antiviral-signaling protein peptide - mouse <br />
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**[[4k8u]], [[3zjb]], [[4m4e]] – hTRAF4 TRAF domain <br />
**[[4k8u]], [[3zjb]], [[4m4e]] – hTRAF4 TRAF domain <br />
 +
**[[2eod]] – hTRAF4 ZF-TRAF domain - NMR<br />
 +
**[[2yuc]] – hTRAF4 zinc finger 1 domain - NMR<br />
**[[5yc1]] – hTRAF4 TRAF domain + GLIB peptide <br />
**[[5yc1]] – hTRAF4 TRAF domain + GLIB peptide <br />
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**[[3hct]], [[3hcu]] – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2<br />
**[[3hct]], [[3hcu]] – hTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2<br />
**[[4z8m]] – hTRAF6 TRAF domain + antiviral-signaling protein peptide<br />
**[[4z8m]] – hTRAF6 TRAF domain + antiviral-signaling protein peptide<br />
-
**[[5vnz]], [[5vo0]] – TRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2 - zebrafish<br />
+
**[[6a33]], [[5zuj]] – hTRAF6 TRAF domain + TIFA peptide<br />
 +
**[[5vnz]], [[5vo0]] – zfTRAF6 RING+zinc finger 1 domains + ubiquitin-conjugating enzyme E2 - zebrafish<br />
 +
**[[6myd]] – zfTRAF6 TRAF domain + STING CTT peptide<br />
 +
 
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:24, 27 February 2020

Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code 1f3v)

Drag the structure with the mouse to rotate

3D Structures of TNF receptor-associated factor

Updated on 27-February-2020

References

  1. ↑ Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene. 2001 Oct 1;20(44):6482-91. PMID:11607847 doi:http://dx.doi.org/10.1038/sj.onc.1204788
  2. ↑ Hildebrand JM, Yi Z, Buchta CM, Poovassery J, Stunz LL, Bishop GA. Roles of tumor necrosis factor receptor associated factor 3 (TRAF3) and TRAF5 in immune cell functions. Immunol Rev. 2011 Nov;244(1):55-74. doi: 10.1111/j.1600-065X.2011.01055.x. PMID:22017431 doi:http://dx.doi.org/10.1111/j.1600-065X.2011.01055.x
  3. ↑ Arthur JF, Shen Y, Gardiner EE, Coleman L, Murphy D, Kenny D, Andrews RK, Berndt MC. TNF receptor-associated factor 4 (TRAF4) is a novel binding partner of glycoprotein Ib and glycoprotein VI in human platelets. J Thromb Haemost. 2011 Jan;9(1):163-72. doi: 10.1111/j.1538-7836.2010.04091.x. PMID:20946164 doi:http://dx.doi.org/10.1111/j.1538-7836.2010.04091.x
  4. ↑ Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 2000 Jun 23;101(7):777-87. PMID:10892748

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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