1aly

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1aly.gif|left|200px]]
[[Image:1aly.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1aly |SIZE=350|CAPTION= <scene name='initialview01'>1aly</scene>, resolution 2.00&Aring;
+
The line below this paragraph, containing "STRUCTURE_1aly", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1aly| PDB=1aly | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aly FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aly OCA], [http://www.ebi.ac.uk/pdbsum/1aly PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aly RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF HUMAN CD40 LIGAND'''
'''CRYSTAL STRUCTURE OF HUMAN CD40 LIGAND'''
Line 28: Line 25:
[[Category: Karpusas, M.]]
[[Category: Karpusas, M.]]
[[Category: Thomas, D.]]
[[Category: Thomas, D.]]
-
[[Category: cd40 ligand]]
+
[[Category: Cd40 ligand]]
-
[[Category: cd40l]]
+
[[Category: Cd40l]]
-
[[Category: cytokine]]
+
[[Category: Cytokine]]
-
[[Category: hyper-igm syndrome]]
+
[[Category: Hyper-igm syndrome]]
-
[[Category: tnf]]
+
[[Category: Tnf]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 10:26:03 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:43:00 2008''
+

Revision as of 07:26, 2 May 2008

Image:1aly.gif

Template:STRUCTURE 1aly

CRYSTAL STRUCTURE OF HUMAN CD40 LIGAND


Overview

BACKGROUND: The CD40 ligand (CD40L) is a member of the tumor necrosis factor (TNF) family of proteins and is transiently expressed on the surface of activated T cells. The binding of CD40L to CD40, which is expressed on the surface of B cells, provides a critical and unique pathway of cellular activation resulting in antibody isotype switching, regulation of apoptosis, and B cell proliferation and differentiation. Naturally occurring mutations of CD40L result in the clinical hyper-IgM syndrome, characterized by an inability to produce immunoglobulins of the IgG, IgA and IgE isotypes. RESULTS: We have determined the crystal structure of a soluble extracellular fragment of human CD40L to 2 A resolution and with an R factor of 21.8%. Although the molecule forms a trimer similar to that found for other members of the TNF family, such as TNF alpha and lymphotoxin-alpha, and exhibits a similar overall fold, there are considerable differences in several loops including those predicted to be involved in CD40 binding. CONCLUSIONS: The structure suggests that most of the hyper-IgM syndrome mutations affect the folding and stability of the molecule rather than the CD40-binding site directly. Despite the fact that the hyper-IgM syndrome mutations are dispersed in the primary sequence, a large fraction of them are clustered in space in the vicinity of a surface loop, close to the predicted CD40-binding site.

About this Structure

1ALY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

2 A crystal structure of an extracellular fragment of human CD40 ligand., Karpusas M, Hsu YM, Wang JH, Thompson J, Lederman S, Chess L, Thomas D, Structure. 1995 Oct 15;3(10):1031-9. PMID:8589998 Page seeded by OCA on Fri May 2 10:26:03 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1aly"
Personal tools