Topoisomerase
From Proteopedia
(Difference between revisions)
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== Disease == | == Disease == | ||
TOPIIA is highly expressed in colorectal cancer<ref>PMID:19111388</ref>. TOP inhibitors are explored as potential therapeutic agents for treatment of infectious diseases<ref>PMID:17346206</ref>. | TOPIIA is highly expressed in colorectal cancer<ref>PMID:19111388</ref>. TOP inhibitors are explored as potential therapeutic agents for treatment of infectious diseases<ref>PMID:17346206</ref>. | ||
| + | == 3D Structures of Topoisomerase == | ||
| + | [[Topoisomerase 3D structures]] | ||
| + | |||
</StructureSection> | </StructureSection> | ||
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*Topoisomerase I (ATP-independent) | *Topoisomerase I (ATP-independent) | ||
| - | **[[3igc]], [[2h7f]], [[2h7g]] – TOPI+DNA – Smallpox virus<br /> | ||
| - | **[[2gai]], [[2gaj]] – TOPI – ''Thermotoga maritime''<br /> | ||
| - | **[[2f4q]] – TOPIB – ''Deinococcus radiodurans''<br /> | ||
**[[1tl8]], [[1sc7]] – hTOPI+DNA+indenoisoquinoline – human<br /> | **[[1tl8]], [[1sc7]] – hTOPI+DNA+indenoisoquinoline – human<br /> | ||
**[[1seu]] - hTOPI+DNA+indolocarbazole<br /> | **[[1seu]] - hTOPI+DNA+indolocarbazole<br /> | ||
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**[[1k4s]], [[1lpq]], [[1ej9]], [[1a31]], [[1a35]], [[1a36]] – hTOPI+DNA<br /> | **[[1k4s]], [[1lpq]], [[1ej9]], [[1a31]], [[1a35]], [[1a36]] – hTOPI+DNA<br /> | ||
**[[1k4t]] - hTOPI+DNA+topotecan<br /> | **[[1k4t]] - hTOPI+DNA+topotecan<br /> | ||
| + | **[[1ois]] – yTOPI N-terminal - yeast<br /> | ||
**[[1cy0]], [[4rul]] – EcTOPI+DNA - ''Escherichia coli''<br /> | **[[1cy0]], [[4rul]] – EcTOPI+DNA - ''Escherichia coli''<br /> | ||
**[[3px7]] – EcTOPI (mutant) +DNA<br /> | **[[3px7]] – EcTOPI (mutant) +DNA<br /> | ||
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**[[1a41]] – VvTOPI C-terminal – Vaccinia virus<br /> | **[[1a41]] – VvTOPI C-terminal – Vaccinia virus<br /> | ||
**[[1vcc]] – VvTOPI N-terminal<br /> | **[[1vcc]] – VvTOPI N-terminal<br /> | ||
| - | + | **[[5d5h]], [[5uj1]], [[5ujy]] - MtTOPI – ''Mycobacterium tuberculosis''<br /> | |
| - | **[[5d5h]], [[ | + | |
**[[6cq2]], [[6cqi]] – MtTOPI + DNA<br /> | **[[6cq2]], [[6cqi]] – MtTOPI + DNA<br /> | ||
| + | **[[3igc]], [[2h7f]], [[2h7g]] – TOPI+DNA – Smallpox virus<br /> | ||
| + | **[[2gai]], [[2gaj]] – TOPI – ''Thermotoga maritime''<br /> | ||
| + | **[[2f4q]] – TOPIB – ''Deinococcus radiodurans''<br /> | ||
| + | **[[6ozw]] – TOPI N terminal – ''Streptococcus mutans''<br /> | ||
*Topoisomerase I (ATP-dependent) is reverse gyrase. See [[Gyrase]] | *Topoisomerase I (ATP-dependent) is reverse gyrase. See [[Gyrase]] | ||
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*TOPII see [[Gyrase]] | *TOPII see [[Gyrase]] | ||
| - | *Topoisomerase IIA | + | *Topoisomerase IIA or DNA gyrase |
| + | **[[1zxm]] – hTOPIIA+AMP-PNP <br /> | ||
| + | **[[1zxn]], [[4r1f]] - hTOPIIA+ADP<br /> | ||
| + | **[[4fm9]] - hTOPIIA+DNA<br /> | ||
| + | **[[5gwk]] - hTOPIIA+DNA + drug<br /> | ||
**[[3l4j]] – yTOPII apo+DNA <br /> | **[[3l4j]] – yTOPII apo+DNA <br /> | ||
**[[3l4k]] - yTOPII+DNA+Zn<br /> | **[[3l4k]] - yTOPII+DNA+Zn<br /> | ||
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**[[1bjt]], [[1bgw]] – yTOPII core<br /> | **[[1bjt]], [[1bgw]] – yTOPII core<br /> | ||
**[[3ksa]], [[2ksb]] – SpTOPIIA+DNA – ''Streptococcus pneumoniae''<br /> | **[[3ksa]], [[2ksb]] – SpTOPIIA+DNA – ''Streptococcus pneumoniae''<br /> | ||
| - | **[[1zxm]] – hTOPIIA+AMP-PNP <br /> | ||
| - | **[[1zxn]], [[4r1f]] - hTOPIIA+ADP<br /> | ||
| - | **[[4fm9]] - hTOPIIA+DNA<br /> | ||
| - | **[[5gwk]] - hTOPIIA+DNA + drug<br /> | ||
**[[4elz]] – TOPII residues 362-493 + CCDB – ''Vibrio fischeri''<br /> | **[[4elz]] – TOPII residues 362-493 + CCDB – ''Vibrio fischeri''<br /> | ||
| + | **[[6rkw]], [[6rks]], [[6rku]], [[6rkv]] - EcTOPIIA subunit A+B + DNA – Cryo EM<br /> | ||
| + | **[[6f94]], [[6f8j]], [[6f86]] - EcTOPIIA subunit B + inhibitor<br /> | ||
| + | **[[6eng]] - EcTOPIIA subunit B ATPase domain + aminocoumarin<br /> | ||
| + | **[[6gav]], [[6gau]] - MtTOPIIA subunit A+B <br /> | ||
*Topoisomerase IIB topo VI | *Topoisomerase IIB topo VI | ||
| + | **[[4j3n]] - hTOPIIB subunit A+B + DNA <br /> | ||
| + | **[[5zrf]] - hTOPIIB subunit B + DNA <br /> | ||
| + | **[[5z9n]], [[5z9m]], [[5z9l]], [[5z9f]], [[5z9e]], [[5z9b]], [[5z4o]], [[5z4h]] - hTOPIIB subunit B + inhibitor <br /> | ||
| + | **[[4g0w]], [[3qx3]], [[4g0v]], [[4g0u]], [[5gwj]], [[5gwi]] - hTOPIIB + DNA + anti-cancer drug<br /> | ||
**[[2zbk]] – SsTOPIIB subunit A+B – ''Sulfolobus shibatae''<br /> | **[[2zbk]] – SsTOPIIB subunit A+B – ''Sulfolobus shibatae''<br /> | ||
**[[2hkj]], [[1mu5]], [[1mx0]] - SsTOPIIB subunit B<br /> | **[[2hkj]], [[1mu5]], [[1mx0]] - SsTOPIIB subunit B<br /> | ||
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**[[2q2e]] - TOPIIB subunit A+B – ''Methanosarcina mazei''<br /> | **[[2q2e]] - TOPIIB subunit A+B – ''Methanosarcina mazei''<br /> | ||
**[[1d3y]] - TOPIIB subunit A - ''Methanocaldococcus janaschii''<br /> | **[[1d3y]] - TOPIIB subunit A - ''Methanocaldococcus janaschii''<br /> | ||
| - | **[[4j3n]] - hTOPIIB subunit A+B + DNA <br /> | ||
| - | **[[4g0w]], [[3qx3]], [[4g0v]], [[4g0u]], [[5gwj]], [[5gwi]] - hTOPIIB + DNA + anti-cancer drug<br /> | ||
*Topoisomerase III | *Topoisomerase III | ||
| - | **[[2o19]], [[2o54]], [[2o59]], [[2o5c]], [[2o5e]], [[1i7d]] – EcTOPIII+DNA <br /> | ||
| - | **[[1d6m]] - EcTOPIII<br /> | ||
**[[4cgy]], [[4cht]] – hTOPIIIα + RecQ-mediated genome instability protein<br /> | **[[4cgy]], [[4cht]] – hTOPIIIα + RecQ-mediated genome instability protein<br /> | ||
**[[5gvc]] – hTOPIIIβ topo domain<br /> | **[[5gvc]] – hTOPIIIβ topo domain<br /> | ||
**[[5gve]] – hTOPIIIβ topo domain + Tudor domain-containing protein<br /> | **[[5gve]] – hTOPIIIβ topo domain + Tudor domain-containing protein<br /> | ||
| + | **[[2o19]], [[2o54]], [[2o59]], [[2o5c]], [[2o5e]], [[1i7d]] – EcTOPIII+DNA <br /> | ||
| + | **[[1d6m]] - EcTOPIII<br /> | ||
*Topoisomerase IV | *Topoisomerase IV | ||
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*Topoisomerase IV complexes | *Topoisomerase IV complexes | ||
| + | **[[4hxz]], [[4hy1]] - hTOPIV subunit B + inhibitor<br /> | ||
**[[4hz0]] - EcTOPIV subunit B + inhibitor<br /> | **[[4hz0]] - EcTOPIV subunit B + inhibitor<br /> | ||
**[[4mn4]] - EcTOPIV subunit A + MukB<br /> | **[[4mn4]] - EcTOPIV subunit A + MukB<br /> | ||
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**[[4url]], [[4urn]] - SaTOPIV subunit B N terminal + antibiotic<br /> | **[[4url]], [[4urn]] - SaTOPIV subunit B N terminal + antibiotic<br /> | ||
**[[2xkk]] - AbTOPIV pare+parc subunits + DNA + moxifloxacin<br /> | **[[2xkk]] - AbTOPIV pare+parc subunits + DNA + moxifloxacin<br /> | ||
| - | **[[4hxz]], [[4hy1]] - hTOPIV subunit B + inhibitor<br /> | ||
**[[4hym]], [[4kqv]] - TOPIV subunit B + inhibitor – ''Francisella tularensis''<br /> | **[[4hym]], [[4kqv]] - TOPIV subunit B + inhibitor – ''Francisella tularensis''<br /> | ||
**[[4hz5]] - TOPIV subunit B + inhibitor – ''Enterococcus faecalis''<br /> | **[[4hz5]] - TOPIV subunit B + inhibitor – ''Enterococcus faecalis''<br /> | ||
Revision as of 09:25, 3 March 2020
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GO Annotations
| Database | ID | Symbol | Qualifier | GO Identifier | GO Term Name | Aspect | Evidence | Reference | With | Taxon | Date | Assigned by | Product Form ID |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB | P14294 | topB | GO:0006259 | DNA metabolic process | P | IEA | InterPro2GO | InterPro:IPR006154 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR000380 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR003601 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR003602 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR005738 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR013497 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR013824 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0006265 | DNA topological change | P | IEA | InterPro2GO | InterPro:IPR013825 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0006268 | DNA unwinding involved in replication | P | IEA | InterPro2GO | InterPro:IPR013824 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0006268 | DNA unwinding involved in replication | P | IEA | InterPro2GO | InterPro:IPR013825 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0000166 | nucleotide binding | F | IEA | Swiss-Prot Keywords2GO | SP_KW:KW-0547 | 83333 | 20101127 | UniProtKB | ||
| UniProtKB | P14294 | topB | GO:0003676 | nucleic acid binding | F | IEA | InterPro2GO | InterPro:IPR006154 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR000380 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR003601 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR003602 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR005738 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR013497 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR013824 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | InterPro2GO | InterPro:IPR013825 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003677 | DNA binding | F | IEA | Swiss-Prot Keywords2GO | SP_KW:KW-0238 | 83333 | 20101127 | UniProtKB | ||
| UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | InterPro2GO | InterPro:IPR003601 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | InterPro2GO | InterPro:IPR003602 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | InterPro2GO | InterPro:IPR005738 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | InterPro2GO | InterPro:IPR013497 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | InterPro2GO | InterPro:IPR013824 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | InterPro2GO | InterPro:IPR013825 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003916 | DNA topoisomerase activity | F | IEA | Swiss-Prot Keywords2GO | SP_KW:KW-0799 | 83333 | 20101127 | UniProtKB | ||
| UniProtKB | P14294 | topB | GO:0003917 | DNA topoisomerase type I activity | F | IDA | PMID:6326814 | 83333 | 20100621 | EcoliWiki | |||
| UniProtKB | P14294 | topB | GO:0003917 | DNA topoisomerase type I activity | F | IEA | InterPro2GO | InterPro:IPR000380 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0003917 | DNA topoisomerase type I activity | F | IEA | EC2GO | EC:5.99.1.2 | 83333 | 20100703 | UniProtKB | ||
| UniProtKB | P14294 | topB | GO:0005515 | protein binding | F | IPI | PMID:15690043 | frlR (FRLR_ECOLI) | 83333 | 20101127 | IntAct | ||
| UniProtKB | P14294 | topB | GO:0005524 | ATP binding | F | IEA | Swiss-Prot Keywords2GO | SP_KW:KW-0067 | 83333 | 20101127 | UniProtKB | ||
| UniProtKB | P14294 | topB | GO:0016853 | isomerase activity | F | IEA | Swiss-Prot Keywords2GO | SP_KW:KW-0413 | 83333 | 20101127 | UniProtKB | ||
| UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR000380 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR003601 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR003602 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR005738 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR013497 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR013824 | 83333 | 20101127 | InterPro | ||
| UniProtKB | P14294 | topB | GO:0005694 | chromosome | C | IEA | InterPro2GO | InterPro:IPR013825 | 83333 | 20101127 | InterPro |
Copied from [1] Last updated Dec 2 2010
3D Structures of Topoisomerase
Updated on 03-March-2020
References
- ↑ Champoux JJ. DNA topoisomerases: structure, function, and mechanism. Annu Rev Biochem. 2001;70:369-413. PMID:11395412 doi:http://dx.doi.org/10.1146/annurev.biochem.70.1.369
- ↑ Slesarev AI, Stetter KO, Lake JA, Gellert M, Krah R, Kozyavkin SA. DNA topoisomerase V is a relative of eukaryotic topoisomerase I from a hyperthermophilic prokaryote. Nature. 1993 Aug 19;364(6439):735-7. PMID:8395022 doi:http://dx.doi.org/10.1038/364735a0
- ↑ Coss A, Tosetto M, Fox EJ, Sapetto-Rebow B, Gorman S, Kennedy BN, Lloyd AT, Hyland JM, O'Donoghue DP, Sheahan K, Leahy DT, Mulcahy HE, O'Sullivan JN. Increased topoisomerase IIalpha expression in colorectal cancer is associated with advanced disease and chemotherapeutic resistance via inhibition of apoptosis. Cancer Lett. 2009 Apr 18;276(2):228-38. doi: 10.1016/j.canlet.2008.11.018. Epub, 2008 Dec 25. PMID:19111388 doi:http://dx.doi.org/10.1016/j.canlet.2008.11.018
- ↑ Tse-Dinh YC. Exploring DNA topoisomerases as targets of novel therapeutic agents in the treatment of infectious diseases. Infect Disord Drug Targets. 2007 Mar;7(1):3-9. PMID:17346206
Created with the participation of Sonny Zhao.
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