6le5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6le5 is ON HOLD until Paper Publication
+
==Crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer (MICU1-MICU2 heterodimer) in an apo state==
-
 
+
<StructureSection load='6le5' size='340' side='right'caption='[[6le5]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-
Authors: Park, J., Lee, Y., Park, T., Kang, J.Y., Jin, M., Yang, J., Eom, S.H.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6le5]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LE5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LE5 FirstGlance]. <br>
-
Description: Crystal structure of Ca2+-free mitochondrial calcium binding protein
+
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6le5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6le5 OCA], [http://pdbe.org/6le5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6le5 RCSB], [http://www.ebi.ac.uk/pdbsum/6le5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6le5 ProSAT]</span></td></tr>
-
[[Category: Kang, J.Y]]
+
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/MICU1_HUMAN MICU1_HUMAN]] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. Acts as a gatekeeper that senses calcium level via its EF-hand domains and sets a threshold for mitochondrial calcium uptake by MCU, thereby preventing mitochondrial calcium overload. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.<ref>PMID:16002733</ref> <ref>PMID:20693986</ref> <ref>PMID:23101630</ref> <ref>PMID:22904319</ref> [[http://www.uniprot.org/uniprot/MICU2_HUMAN MICU2_HUMAN]] Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low (PubMed:24503055, PubMed:24560927, PubMed:26903221). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering (PubMed:24560927).<ref>PMID:24503055</ref> <ref>PMID:24560927</ref> <ref>PMID:26387864</ref> <ref>PMID:26903221</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
 +
[[Category: Eom, S H]]
 +
[[Category: Jin, M]]
 +
[[Category: Kang, J Y]]
 +
[[Category: Lee, Y]]
 +
[[Category: Park, J]]
 +
[[Category: Park, T]]
[[Category: Yang, J]]
[[Category: Yang, J]]
-
[[Category: Park, T]]
+
[[Category: Complex]]
-
[[Category: Park, J]]
+
[[Category: Metal binding protein]]
-
[[Category: Lee, Y]]
+
[[Category: Mitochondrial calcium uptake 1 and mitochondrial calcium uptake 2]]
-
[[Category: Eom, S.H]]
+
-
[[Category: Jin, M]]
+

Revision as of 06:42, 4 March 2020

Crystal structure of the mitochondrial calcium uptake 1 and 2 heterodimer (MICU1-MICU2 heterodimer) in an apo state

PDB ID 6le5

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6le5"
Personal tools