6luq

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m (Protected "6luq" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6luq is ON HOLD until Paper Publication
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==Haloperidol bound D2 dopamine receptor structure inspired discovery of subtype selective ligands==
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<StructureSection load='6luq' size='340' side='right'caption='[[6luq]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6luq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LUQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6LUQ FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GMJ:4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one'>GMJ</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6luq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6luq OCA], [http://pdbe.org/6luq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6luq RCSB], [http://www.ebi.ac.uk/pdbsum/6luq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6luq ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/DRD2_HUMAN DRD2_HUMAN]] Myoclonic dystonia 11. The gene represented in this entry may be involved in disease pathogenesis. DRD2 mutations in myoclonic dystonia patients are rare, and their contribution to disease phenotype is unclear (PubMed:10716258).
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== Function ==
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[[http://www.uniprot.org/uniprot/DRD2_HUMAN DRD2_HUMAN]] Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity).<ref>PMID:21645528</ref> <ref>PMID:17264214</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Lysozyme]]
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[[Category: Chen, Z]]
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[[Category: Cheng, J]]
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[[Category: Fan, L]]
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[[Category: Luo, Z]]
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[[Category: Nie, F]]
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[[Category: Qi, J]]
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[[Category: Tan, L]]
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[[Category: Wang, S]]
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[[Category: D2 dopamine receptor]]
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[[Category: Dopamine receptor]]
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[[Category: Gpcr]]
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[[Category: Haloperidol]]
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[[Category: Membrane protein]]

Revision as of 06:42, 4 March 2020

Haloperidol bound D2 dopamine receptor structure inspired discovery of subtype selective ligands

PDB ID 6luq

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