6o4u
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Co-crystal structure of Mcl1 with inhibitor== | |
| - | + | <StructureSection load='6o4u' size='340' side='right'caption='[[6o4u]], [[Resolution|resolution]] 1.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6o4u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O4U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O4U FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LMV:(2~{S})-4-(cyclobutylmethyl)-2-(2,4-dichlorophenyl)-~{N}-(2-methylpropylsulfonyl)-2,3-dihydro-1,4-benzoxazine-6-carboxamide'>LMV</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o4u OCA], [http://pdbe.org/6o4u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o4u RCSB], [http://www.ebi.ac.uk/pdbsum/6o4u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o4u ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Huang, X]] | [[Category: Huang, X]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Apoptosis-inhibitor complex]] | ||
| + | [[Category: Inhibitor]] | ||
Revision as of 06:43, 4 March 2020
Co-crystal structure of Mcl1 with inhibitor
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