6p0m

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m (Protected "6p0m" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6p0m is ON HOLD until Paper Publication
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==Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds.==
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<StructureSection load='6p0m' size='340' side='right'caption='[[6p0m]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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Authors: Bum-Erdene, K., Gonzalez-Gutierrez, G., Liu, D., Ghozayel, M.K., Xu, D., Meroueh, S.O.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6p0m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6P0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6P0M FirstGlance]. <br>
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Description: Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NLM:4-[(3-chloropyridin-2-yl)sulfamoyl]benzene-1-sulfonic+acid'>NLM</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6p0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6p0m OCA], [http://pdbe.org/6p0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6p0m RCSB], [http://www.ebi.ac.uk/pdbsum/6p0m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6p0m ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RALA_HUMAN RALA_HUMAN]] Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.<ref>PMID:18756269</ref> <ref>PMID:19306925</ref> <ref>PMID:20005108</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Bum-Erdene, K]]
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[[Category: Ghozayel, M K]]
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[[Category: Gonzalez-Gutierrez, G]]
[[Category: Liu, D]]
[[Category: Liu, D]]
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[[Category: Meroueh, S.O]]
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[[Category: Meroueh, S O]]
[[Category: Xu, D]]
[[Category: Xu, D]]
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[[Category: Ghozayel, M.K]]
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[[Category: Covalent inhibitor]]
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[[Category: Bum-Erdene, K]]
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[[Category: Ral gtpase]]
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[[Category: Gonzalez-Gutierrez, G]]
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[[Category: Rala]]
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[[Category: Signaling protein]]
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[[Category: Signaling protein-inhibitor complex]]
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[[Category: Sulfonyl fluoride]]

Revision as of 06:44, 4 March 2020

Crystal structure of GDP-bound human RalA in a covalent complex with aryl sulfonyl fluoride compounds.

PDB ID 6p0m

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OCA

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