6ttw

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m (Protected "6ttw" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6ttw is ON HOLD
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==Crystal structure of the human METTL3-METTL14 complex bound to Compound 4 (ASI_M3M_047)==
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<StructureSection load='6ttw' size='340' side='right'caption='[[6ttw]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors: Bedi, R.K., Huang, D., Sledz, P., Caflisch, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6ttw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TTW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TTW FirstGlance]. <br>
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Description: Crystal structure of the human METTL3-METTL14 complex bound to Compound 4 (ASI_M3M_047)
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=NWZ:(2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)-~{N}-piperidin-4-yl-oxolane-2-carboxamide'>NWZ</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/mRNA_m(6)A_methyltransferase mRNA m(6)A methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.348 2.1.1.348] </span></td></tr>
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[[Category: Sledz, P]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ttw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ttw OCA], [http://pdbe.org/6ttw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ttw RCSB], [http://www.ebi.ac.uk/pdbsum/6ttw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ttw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MTA70_HUMAN MTA70_HUMAN]] N6-methyltransferase that methylates adenosine residues of some RNAs and acts as a regulator of the circadian clock, differentiation of embryonic stem cells and primary miRNA processing. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability (PubMed:22575960, PubMed:24284625, PubMed:25719671, PubMed:25799998, PubMed:26321680, PubMed:26593424, PubMed:9409616). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop by putting mRNA production on a fast-track for facilitating nuclear processing, thereby providing an early point of control in setting the dynamics of the feedback loop (By similarity). M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization, promoting differentiation of ESCs (By similarity). M6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs) (PubMed:25799998). Mediates methylation of pri-miRNAs, marking them for recognition and processing by DGCR8 (PubMed:25799998).[UniProtKB:Q8C3P7]<ref>PMID:22575960</ref> <ref>PMID:24284625</ref> <ref>PMID:25719671</ref> <ref>PMID:25799998</ref> <ref>PMID:26321680</ref> <ref>PMID:26593424</ref> <ref>PMID:9409616</ref> [[http://www.uniprot.org/uniprot/MET14_HUMAN MET14_HUMAN]] N6-methyltransferase that methylates adenosine residues of some mRNAs and acts as a regulator of the circadian clock and differentiation of embryonic stem cells. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in the efficiency of mRNA splicing, processing and mRNA stability (PubMed:24316715, PubMed:24407421, PubMed:25719671). M6A regulates the length of the circadian clock: acts as a early pace-setter in the circadian loop. M6A also acts as a regulator of mRNA stability: in embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity).[UniProtKB:Q3UIK4]<ref>PMID:24316715</ref> <ref>PMID:24407421</ref> <ref>PMID:25719671</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Bedi, R K]]
[[Category: Caflisch, A]]
[[Category: Caflisch, A]]
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[[Category: Bedi, R.K]]
 
[[Category: Huang, D]]
[[Category: Huang, D]]
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[[Category: Sledz, P]]
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[[Category: Complex]]
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[[Category: Compound]]
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[[Category: Epitranscriptomic]]
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[[Category: Mettl14]]
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[[Category: Mettl3]]
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[[Category: Transferase]]

Revision as of 06:54, 4 March 2020

Crystal structure of the human METTL3-METTL14 complex bound to Compound 4 (ASI_M3M_047)

PDB ID 6ttw

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