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6uc6
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-H11== | |
| - | + | <StructureSection load='6uc6' size='340' side='right'caption='[[6uc6]], [[Resolution|resolution]] 2.32Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6uc6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UC6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UC6 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uc6 OCA], [http://pdbe.org/6uc6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uc6 RCSB], [http://www.ebi.ac.uk/pdbsum/6uc6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uc6 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bontoxilysin]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Jin, R]] | ||
| + | [[Category: Lam, K]] | ||
| + | [[Category: Antitoxin]] | ||
| + | [[Category: Hydrolase-antitoxin complex]] | ||
| + | [[Category: Receptor-binding domain]] | ||
| + | [[Category: Toxin]] | ||
| + | [[Category: Vhh]] | ||
Revision as of 06:55, 4 March 2020
Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-H11
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