6uht
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-G10== | |
| - | + | <StructureSection load='6uht' size='340' side='right'caption='[[6uht]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6uht]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6UHT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6UHT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6uht FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6uht OCA], [http://pdbe.org/6uht PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6uht RCSB], [http://www.ebi.ac.uk/pdbsum/6uht PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6uht ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bontoxilysin]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Jin, R]] | ||
| + | [[Category: Lam, K]] | ||
| + | [[Category: Antitoxin]] | ||
| + | [[Category: Receptor-binding domain]] | ||
| + | [[Category: Toxin]] | ||
| + | [[Category: Toxin-antitoxin complex]] | ||
| + | [[Category: Vhh]] | ||
Revision as of 06:55, 4 March 2020
Crystal structure of BoNT/B receptor-binding domain in complex with VHH JLI-G10
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