5ds1
From Proteopedia
(Difference between revisions)
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==Core domain of the class II small heat-shock protein HSP 17.7 from Pisum sativum== | ==Core domain of the class II small heat-shock protein HSP 17.7 from Pisum sativum== | ||
| - | <StructureSection load='5ds1' size='340' side='right' caption='[[5ds1]], [[Resolution|resolution]] 2.63Å' scene=''> | + | <StructureSection load='5ds1' size='340' side='right'caption='[[5ds1]], [[Resolution|resolution]] 2.63Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5ds1]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DS1 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5ds1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Garden_pea Garden pea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DS1 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ds1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ds1 OCA], [http://pdbe.org/5ds1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ds1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ds1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ds1 ProSAT]</span></td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP17.7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3888 Garden pea])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ds1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ds1 OCA], [http://pdbe.org/5ds1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ds1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ds1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ds1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Oligomeric proteins assemble with exceptional selectivity, even in the presence of closely related proteins, to perform their cellular roles. We show that most proteins related by gene duplication of an oligomeric ancestor have evolved to avoid hetero-oligomerization and that this correlates with their acquisition of distinct functions. We report how coassembly is avoided by two oligomeric small heat-shock protein paralogs. A hierarchy of assembly, involving intermediates that are populated only fleetingly at equilibrium, ensures selective oligomerization. Conformational flexibility at noninterfacial regions in the monomers prevents coassembly, allowing interfaces to remain largely conserved. Homomeric oligomers must overcome the entropic benefit of coassembly and, accordingly, homomeric paralogs comprise fewer subunits than homomers that have no paralogs. | ||
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| + | Structural principles that enable oligomeric small heat-shock protein paralogs to evolve distinct functions.,Hochberg GKA, Shepherd DA, Marklund EG, Santhanagoplan I, Degiacomi MT, Laganowsky A, Allison TM, Basha E, Marty MT, Galpin MR, Struwe WB, Baldwin AJ, Vierling E, Benesch JLP Science. 2018 Feb 23;359(6378):930-935. doi: 10.1126/science.aam7229. PMID:29472485<ref>PMID:29472485</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5ds1" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Garden pea]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Allison, T A]] | [[Category: Allison, T A]] | ||
[[Category: Benesch, J L.P]] | [[Category: Benesch, J L.P]] | ||
Revision as of 07:03, 4 March 2020
Core domain of the class II small heat-shock protein HSP 17.7 from Pisum sativum
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